Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yeeU/CbtA-CbeA |
| Location | 4090170..4090877 | Replicon | chromosome |
| Accession | NZ_CP055030 | ||
| Organism | Shigella flexneri strain SWHEFF_64 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | A0A377AQ31 |
| Locus tag | HUZ74_RS19915 | Protein ID | WP_032161355.1 |
| Coordinates | 4090170..4090511 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HUZ74_RS19920 | Protein ID | WP_032161354.1 |
| Coordinates | 4090542..4090877 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ74_RS19875 (4085571) | 4085571..4085735 | + | 165 | WP_001593927.1 | DUF1127 domain-containing protein | - |
| HUZ74_RS19880 (4085832) | 4085832..4086077 | + | 246 | Protein_3907 | DUF262 domain-containing protein | - |
| HUZ74_RS19885 (4086134) | 4086134..4086831 | + | 698 | WP_223369285.1 | IS1-like element IS1A family transposase | - |
| HUZ74_RS19890 (4086936) | 4086936..4087079 | + | 144 | Protein_3909 | HNH endonuclease | - |
| HUZ74_RS19895 (4087713) | 4087713..4088501 | - | 789 | WP_032161357.1 | helix-turn-helix domain-containing protein | - |
| HUZ74_RS19900 (4088618) | 4088618..4088893 | - | 276 | WP_001683517.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HUZ74_RS19905 (4088897) | 4088897..4089145 | - | 249 | WP_024187601.1 | ribbon-helix-helix domain-containing protein | - |
| HUZ74_RS19910 (4089222) | 4089222..4090055 | - | 834 | WP_032250394.1 | DUF4942 domain-containing protein | - |
| HUZ74_RS19915 (4090170) | 4090170..4090511 | - | 342 | WP_032161355.1 | TA system toxin CbtA family protein | Toxin |
| HUZ74_RS19920 (4090542) | 4090542..4090877 | - | 336 | WP_032161354.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HUZ74_RS19925 (4090877) | 4090877..4091350 | - | 474 | WP_032161353.1 | DNA repair protein RadC | - |
| HUZ74_RS19930 (4091380) | 4091380..4092198 | - | 819 | WP_001683514.1 | DUF932 domain-containing protein | - |
| HUZ74_RS19935 (4092434) | 4092434..4092913 | - | 480 | WP_239594486.1 | hypothetical protein | - |
| HUZ74_RS19945 (4093706) | 4093706..4094158 | + | 453 | WP_152925145.1 | hypothetical protein | - |
| HUZ74_RS19950 (4094382) | 4094382..4095362 | - | 981 | WP_000019450.1 | IS5-like element ISKpn26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4085571..4095980 | 10409 | |
| - | flank | IS/Tn | - | - | 4086454..4086831 | 377 | |
| - | flank | IS/Tn | - | - | 4094382..4095362 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13048.01 Da Isoelectric Point: 9.8953
>T161115 WP_032161355.1 NZ_CP055030:c4090511-4090170 [Shigella flexneri]
MKIIPATTLRATTSYLSPVVVWQTLLTRLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRSHNTTAR
MKIIPATTLRATTSYLSPVVVWQTLLTRLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRSHNTTAR
Download Length: 342 bp
>T161115 NZ_CP071030:17688-18104 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12530.56 Da Isoelectric Point: 8.1281
>AT161115 WP_032161354.1 NZ_CP055030:c4090877-4090542 [Shigella flexneri]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSACQKR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSACQKR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
Download Length: 336 bp
>AT161115 NZ_CP071030:17461-17691 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|