Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1106101..1106936 Replicon chromosome
Accession NZ_CP055030
Organism Shigella flexneri strain SWHEFF_64

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P1YKV1
Locus tag HUZ74_RS05345 Protein ID WP_016240657.1
Coordinates 1106101..1106478 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L4CDD9
Locus tag HUZ74_RS05350 Protein ID WP_016240658.1
Coordinates 1106568..1106936 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ74_RS05320 (1101479) 1101479..1103731 - 2253 Protein_1043 alpha-amylase family glycosyl hydrolase -
HUZ74_RS05330 (1104465) 1104465..1105310 - 846 WP_001280435.1 DUF4942 domain-containing protein -
HUZ74_RS05335 (1105407) 1105407..1105604 - 198 WP_000839263.1 DUF957 domain-containing protein -
HUZ74_RS05340 (1105616) 1105616..1106104 - 489 WP_016240656.1 DUF5983 family protein -
HUZ74_RS05345 (1106101) 1106101..1106478 - 378 WP_016240657.1 TA system toxin CbtA family protein Toxin
HUZ74_RS05350 (1106568) 1106568..1106936 - 369 WP_016240658.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ74_RS05355 (1106986) 1106986..1107630 - 645 WP_016240659.1 hypothetical protein -
HUZ74_RS05360 (1107649) 1107649..1107870 - 222 WP_000692353.1 DUF987 domain-containing protein -
HUZ74_RS05365 (1107939) 1107939..1108415 - 477 WP_016240660.1 RadC family protein -
HUZ74_RS05370 (1108430) 1108430..1108915 - 486 WP_000214317.1 antirestriction protein -
HUZ74_RS05375 (1109006) 1109006..1109824 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1102694..1135001 32307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14192.16 Da        Isoelectric Point: 8.2905

>T161098 WP_016240657.1 NZ_CP055030:c1106478-1106101 [Shigella flexneri]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T161098 NZ_CP071025:c4605833-4605522 [Enterobacter hormaechei]
ATGCTATTCATTGAAACGGATATTTTTACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATAGGTTCCAAAT
ATTCCTGGCAACGCAACCGGATTACGGCGATCTGATCCAGAATACGGGAGGCTTGCGAAAGATTCGCTGGCTTGCTGGCG
GTAAGGGAAAGCGTAGTGGAGTCAGAGTTATCTATTTTCACCGTACGCGTGAGTGTGAAATCAGGTTGCTGCTCATCTAT
CGCAAAGGGATCAAAGATGACCTCTCCGCGGGTGAAAAAGCCATACTGAAAAAGATGATTGAGAGGTGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13876.58 Da        Isoelectric Point: 5.9652

>AT161098 WP_016240658.1 NZ_CP055030:c1106936-1106568 [Shigella flexneri]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRDGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT161098 NZ_CP071025:c4605521-4605231 [Enterobacter hormaechei]
ATGGATAAGGCGCTGTTTGAGCGATTAACCCAAAGCATTGCGCAAATCAACGAAATTGCCGAGGGCCAACGAGAGCCGTC
GCGTACGTTTCAAATTGATGCGATGAAAATAAAAGAAATTCGTCAGGCGTCCGGGTTGTCGCAGAGTAAATTCGCGAACT
TAATCTCAGTTAGCGTTGATACGTTGCGTAACTGGGAACAAGGCAGACGCTCACCTACAGGCCCCGCTAAAGCGCTATTG
CGCGCCATTGCTAACGACCCTCAACATGTCATCCCAGCCCTAACGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P1YKV1

Antitoxin

Source ID Structure
AlphaFold DB A0A3L4CDD9

References