Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2364523..2365161 Replicon chromosome
Accession NZ_CP055024
Organism Shigella flexneri strain SWHEFF_67

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUZ75_RS11490 Protein ID WP_000813794.1
Coordinates 2364985..2365161 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUZ75_RS11485 Protein ID WP_001270286.1
Coordinates 2364523..2364939 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ75_RS11465 (2359675) 2359675..2360616 - 942 WP_239616598.1 ABC transporter permease -
HUZ75_RS11470 (2360617) 2360617..2361630 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
HUZ75_RS11475 (2361648) 2361648..2362793 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HUZ75_RS11480 (2363038) 2363038..2364444 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
HUZ75_RS11485 (2364523) 2364523..2364939 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUZ75_RS11490 (2364985) 2364985..2365161 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUZ75_RS11495 (2365383) 2365383..2365613 + 231 WP_000494244.1 YncJ family protein -
HUZ75_RS11500 (2365705) 2365705..2367666 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUZ75_RS11505 (2367739) 2367739..2368275 - 537 WP_239616601.1 DNA-binding transcriptional regulator SutR -
HUZ75_RS11510 (2368367) 2368367..2369542 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2369582..2370847 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T161085 WP_000813794.1 NZ_CP055024:c2365161-2364985 [Shigella flexneri]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T161085 NZ_CP071023:c2708342-2708239 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT161085 WP_001270286.1 NZ_CP055024:c2364939-2364523 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT161085 NZ_CP071023:2708234-2708435 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References