Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1999217..2000061 Replicon chromosome
Accession NZ_CP055019
Organism Escherichia coli strain SWHEFF_69

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag HUZ77_RS09315 Protein ID WP_000854686.1
Coordinates 1999678..2000061 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HUZ77_RS09310 Protein ID WP_219365756.1
Coordinates 1999217..1999597 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ77_RS09275 (1995465) 1995465..1995920 + 456 WP_000581506.1 IrmA family protein -
HUZ77_RS09280 (1996021) 1996021..1996229 + 209 Protein_1821 DUF905 family protein -
HUZ77_RS09285 (1996330) 1996330..1997151 + 822 WP_001761104.1 DUF932 domain-containing protein -
HUZ77_RS09290 (1997243) 1997243..1997728 + 486 WP_000214307.1 antirestriction protein -
HUZ77_RS09295 (1997744) 1997744..1998220 + 477 WP_001186726.1 RadC family protein -
HUZ77_RS09300 (1998283) 1998283..1998504 + 222 WP_000692298.1 DUF987 domain-containing protein -
HUZ77_RS09305 (1998523) 1998523..1999206 + 684 WP_000086768.1 hypothetical protein -
HUZ77_RS09310 (1999217) 1999217..1999597 + 381 WP_219365756.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ77_RS09315 (1999678) 1999678..2000061 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
HUZ77_RS09320 (2000058) 2000058..2000546 + 489 WP_032180032.1 DUF5983 family protein -
HUZ77_RS09325 (2000563) 2000563..2000760 + 198 WP_000839253.1 DUF957 domain-containing protein -
HUZ77_RS09330 (2000845) 2000845..2001686 + 842 Protein_1831 DUF4942 domain-containing protein -
HUZ77_RS09340 (2002157) 2002157..2003095 + 939 WP_061092643.1 glyoxylate/hydroxypyruvate reductase GhrA -
HUZ77_RS09345 (2003150) 2003150..2003887 + 738 WP_061092644.1 zinc-binding phosphatase -
HUZ77_RS09350 (2003911) 2003911..2004465 + 555 WP_001001920.1 molecular chaperone YcdY -
HUZ77_RS09355 (2004567) 2004567..2005058 + 492 WP_001308552.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgG / csgF / csgE / csgD / csgB / csgA / csgC 1953033..2010625 57592


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T161018 WP_000854686.1 NZ_CP055019:1999678-2000061 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T161018 NZ_CP071007:5332903-5333313 [Pseudomonas sp. SORT22]
ATGCTCAAGTACATGCTCGATACCAACATCTGCATCTTCACCCTCAAGAACAAGCCTCTGGTCGTACGTGAAGCATTCAA
TCGCCATTACGGCCAACTGTGCATCAGCACAGTGACGCTGATGGAATTGATGTATGGCGCTGAAAAATCCGCTGCACCTG
AACGCAATCTTGCCGTAGTCGAAGGATTCGCCGCACGCCTGGAGGTCCTCAGTTACGATGACCGTGCTGCGGCTCACAGC
GGTCAGTTGCGTGCAGAGTTGGCCCGAGCCGGAACACCGATTGGCCCCTATGACCAGATGATTGCCGGACATGCGCGTTC
ATTGGGGTTGCTACTGGTAACCAACAACATCCGCGAATTCCAGCGTGTTCCTGGGCTGCGCGTGGAAGACTGGCTCAACC
CCGCTCAATAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13954.73 Da        Isoelectric Point: 5.0823

>AT161018 WP_219365756.1 NZ_CP055019:1999217-1999597 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPLE

Download         Length: 381 bp

>AT161018 NZ_CP071007:5332673-5332903 [Pseudomonas sp. SORT22]
ATGGAGCAAGGTGCCGTCTTCAAGAGCAACCGCAGCCAAGCTGTGCGCCTGCCCAAGTCCGTAGCCCTGCCAGAGGATGT
CAAACGCGTGGATATAGTCGCAGTGGGGCGAACCCGAATTATTTCTCCCTCCGGTGAAGCCTGGGACAGCTGGTTCGAAG
GTCAGGATGTCAGCCCGGACTTCATGGCCGAACGTGAGCAAGACACCGATCAGGAGCGTGAGGGGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References