Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 352198..352829 | Replicon | chromosome |
| Accession | NZ_CP055019 | ||
| Organism | Escherichia coli strain SWHEFF_69 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | L4J012 |
| Locus tag | HUZ77_RS01605 | Protein ID | WP_001260301.1 |
| Coordinates | 352198..352473 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | U9Y7E1 |
| Locus tag | HUZ77_RS01610 | Protein ID | WP_000593555.1 |
| Coordinates | 352470..352829 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ77_RS01590 (347202) | 347202..348269 | + | 1068 | WP_000361497.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| HUZ77_RS01595 (348266) | 348266..351001 | + | 2736 | WP_061092822.1 | ribosome-associated ATPase/putative transporter RbbA | - |
| HUZ77_RS01600 (351001) | 351001..352125 | + | 1125 | WP_001314210.1 | ABC transporter permease | - |
| HUZ77_RS01605 (352198) | 352198..352473 | + | 276 | WP_001260301.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| HUZ77_RS01610 (352470) | 352470..352829 | + | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| HUZ77_RS01615 (352949) | 352949..353350 | - | 402 | WP_001190062.1 | nickel-responsive transcriptional regulator NikR | - |
| HUZ77_RS01620 (353355) | 353355..354161 | - | 807 | WP_061092823.1 | nickel import ATP-binding protein NikE | - |
| HUZ77_RS01625 (354158) | 354158..354922 | - | 765 | WP_001136211.1 | nickel import ATP-binding protein NikD | - |
| HUZ77_RS01630 (354922) | 354922..355755 | - | 834 | WP_001008963.1 | nickel ABC transporter permease subunit NikC | - |
| HUZ77_RS01635 (355752) | 355752..356696 | - | 945 | WP_000947080.1 | nickel ABC transporter permease subunit NikB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 345214..353350 | 8136 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10185.87 Da Isoelectric Point: 10.6128
>T161011 WP_001260301.1 NZ_CP055019:352198-352473 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
Download Length: 276 bp
>T161011 NZ_CP070997:1721268-1721432 [Acinetobacter indicus]
ATGTCTAGAGGTGATAAGTCGGCCTATACCGACAAGCAGAAACGTCAGGCCCGCCATATTATTGAATCGGAAAAAGAGCG
AGGCCATTCCGAAGAAGAAGCAGAACGCATTGGCTGGTCTACCGTCAATAAACAGGATGGCGGCGGTAAAAAGAAATCTC
ACTAA
ATGTCTAGAGGTGATAAGTCGGCCTATACCGACAAGCAGAAACGTCAGGCCCGCCATATTATTGAATCGGAAAAAGAGCG
AGGCCATTCCGAAGAAGAAGCAGAACGCATTGGCTGGTCTACCGTCAATAAACAGGATGGCGGCGGTAAAAAGAAATCTC
ACTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13402.27 Da Isoelectric Point: 5.1987
>AT161011 WP_000593555.1 NZ_CP055019:352470-352829 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
Download Length: 360 bp
>AT161011 NZ_CP070997:1720317-1721186 [Acinetobacter indicus]
ATGAATCATTATCCTGACAGCCCATCTCCGCAAGAGAAACAGGAGCATCAGCCTGGTGTACAATATAAAATGACGCCCGA
ACCTGAAATTATTAAAAGCAATTATCAGGGCAGTCAAAAACTCAAAGACAAGGTAGCTTTAATTACCGGCGGTGATAGCG
GCATCGGCCGATCTGTGGCGGTGCTGTTTGCCCGCGAAGGTGCCAATATTATTATTCCCTATTTAGAAGAAGATCAAGAT
GCGCAAGACACCAAGCGACTGGTTGAGCAGGAAGGCTGTCAATGTCTGCTGATTCAATGTGACCTGCGCCAGCATGCGGC
AGTACAGCAGATGGTCGATCTGGCTTTGCAGCAATTTCCGCATATTAATATTCTGGTCAATAATGCCGCCGTACAATATC
CACAAAAAACCATTGAGGATATTAATCCCGAACAGCTGCATAAAACCTTTGAAACCAACCTCTACCCGCTGTTTTATGTG
ACCCAGTTACTCATTCCTCAAATGCAGCCCGGTGACAGTATTATCAATACCACCAGTATCACCAGCTATCAGGGCCATAA
TGAGCTCATTGATTATGCCAGTACCAAAGGGGCAATTACCGCTTTTACCCGTAGCCTGTCGACCAACCTGCTAAAAAATA
AAACCGGGATTCGGGTGAATGGTGTCGCACCCGGCCCAATCTGGACACCGTTAATTCCAAGCAGTTTTGATGAAGAACAG
CTAAAAGGTTTTGGTGAAGATACCCCCATGGGCCGTATGGGTCAGCCAAGTGAAGTTGCGCCAGCTTATCTGTTTTTAGC
CTCCGATGAAGCCAGCTATATTTCCGGTCAGGTGATTCATGTTAATGGCGGTACTATTGTCAATGGTTAA
ATGAATCATTATCCTGACAGCCCATCTCCGCAAGAGAAACAGGAGCATCAGCCTGGTGTACAATATAAAATGACGCCCGA
ACCTGAAATTATTAAAAGCAATTATCAGGGCAGTCAAAAACTCAAAGACAAGGTAGCTTTAATTACCGGCGGTGATAGCG
GCATCGGCCGATCTGTGGCGGTGCTGTTTGCCCGCGAAGGTGCCAATATTATTATTCCCTATTTAGAAGAAGATCAAGAT
GCGCAAGACACCAAGCGACTGGTTGAGCAGGAAGGCTGTCAATGTCTGCTGATTCAATGTGACCTGCGCCAGCATGCGGC
AGTACAGCAGATGGTCGATCTGGCTTTGCAGCAATTTCCGCATATTAATATTCTGGTCAATAATGCCGCCGTACAATATC
CACAAAAAACCATTGAGGATATTAATCCCGAACAGCTGCATAAAACCTTTGAAACCAACCTCTACCCGCTGTTTTATGTG
ACCCAGTTACTCATTCCTCAAATGCAGCCCGGTGACAGTATTATCAATACCACCAGTATCACCAGCTATCAGGGCCATAA
TGAGCTCATTGATTATGCCAGTACCAAAGGGGCAATTACCGCTTTTACCCGTAGCCTGTCGACCAACCTGCTAAAAAATA
AAACCGGGATTCGGGTGAATGGTGTCGCACCCGGCCCAATCTGGACACCGTTAATTCCAAGCAGTTTTGATGAAGAACAG
CTAAAAGGTTTTGGTGAAGATACCCCCATGGGCCGTATGGGTCAGCCAAGTGAAGTTGCGCCAGCTTATCTGTTTTTAGC
CTCCGATGAAGCCAGCTATATTTCCGGTCAGGTGATTCATGTTAATGGCGGTACTATTGTCAATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | L4J012 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LKZ6 |