Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3461519..3462114 Replicon chromosome
Accession NZ_CP055015
Organism Shigella flexneri strain SWHEFF_71

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HUZ78_RS17155 Protein ID WP_000239579.1
Coordinates 3461764..3462114 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HUZ78_RS17150 Protein ID WP_001223208.1
Coordinates 3461519..3461770 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ78_RS17140 (3457184) 3457184..3460963 + 3780 WP_205850253.1 translocation/assembly module TamB domain-containing protein -
HUZ78_RS17145 (3460966) 3460966..3461307 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HUZ78_RS17150 (3461519) 3461519..3461770 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HUZ78_RS17155 (3461764) 3461764..3462114 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HUZ78_RS17160 (3462194) 3462194..3462724 - 531 WP_000055075.1 inorganic diphosphatase -
HUZ78_RS17165 (3463034) 3463034..3463990 + 957 WP_096942060.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HUZ78_RS17170 (3464130) 3464130..3465632 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
HUZ78_RS17175 (3465646) 3465646..3466668 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T160999 WP_000239579.1 NZ_CP055015:3461764-3462114 [Shigella flexneri]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T160999 NZ_CP070991:1189413-1189601 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCAAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT160999 WP_001223208.1 NZ_CP055015:3461519-3461770 [Shigella flexneri]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT160999 NZ_CP070991:1189124-1189384 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTCTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References