Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2634630..2635216 Replicon chromosome
Accession NZ_CP055015
Organism Shigella flexneri strain SWHEFF_71

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag HUZ78_RS13330 Protein ID WP_042014162.1
Coordinates 2634986..2635216 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag HUZ78_RS13325 Protein ID WP_000593555.1
Coordinates 2634630..2634989 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ78_RS13300 (2630762) 2630762..2631706 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
HUZ78_RS13305 (2631703) 2631703..2632536 + 834 WP_205850291.1 nickel ABC transporter permease subunit NikC -
HUZ78_RS13310 (2632536) 2632536..2633300 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
HUZ78_RS13315 (2633297) 2633297..2634103 + 807 WP_096942142.1 nickel import ATP-binding protein NikE -
HUZ78_RS13320 (2634109) 2634109..2634510 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
HUZ78_RS13325 (2634630) 2634630..2634989 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUZ78_RS13330 (2634986) 2634986..2635216 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
HUZ78_RS13335 (2635320) 2635320..2636444 - 1125 WP_039720250.1 ABC transporter permease -
HUZ78_RS13340 (2636444) 2636444..2639179 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T160996 WP_042014162.1 NZ_CP055015:c2635216-2634986 [Shigella flexneri]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T160996 NZ_CP070991:18899-19075 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT160996 WP_000593555.1 NZ_CP055015:c2634989-2634630 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT160996 NZ_CP070991:c19237-19063 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References