Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1585152..1585777 Replicon chromosome
Accession NZ_CP055015
Organism Shigella flexneri strain SWHEFF_71

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUZ78_RS08035 Protein ID WP_000911330.1
Coordinates 1585152..1585550 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HUZ78_RS08040 Protein ID WP_000450524.1
Coordinates 1585550..1585777 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ78_RS08015 (1581030) 1581030..1581230 + 201 WP_000383836.1 YpfN family protein -
HUZ78_RS08020 (1581340) 1581340..1582038 - 699 WP_000679812.1 esterase -
HUZ78_RS08025 (1582112) 1582112..1584127 - 2016 WP_096942028.1 tRNA cytosine(34) acetyltransferase TmcA -
HUZ78_RS08030 (1584142) 1584142..1585005 - 864 WP_001267507.1 neutral zinc metallopeptidase -
HUZ78_RS08035 (1585152) 1585152..1585550 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
HUZ78_RS08040 (1585550) 1585550..1585777 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HUZ78_RS08045 (1585931) 1585931..1586644 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HUZ78_RS08050 (1586857) 1586857..1587891 - 1035 WP_001358397.1 outer membrane protein assembly factor BamC -
HUZ78_RS08055 (1587908) 1587908..1588786 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
HUZ78_RS08060 (1588932) 1588932..1589504 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
HUZ78_RS08065 (1589504) 1589504..1589974 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T160992 WP_000911330.1 NZ_CP055015:c1585550-1585152 [Shigella flexneri]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T160992 NZ_CP070986:c2184561-2184457 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT160992 WP_000450524.1 NZ_CP055015:c1585777-1585550 [Shigella flexneri]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT160992 NZ_CP070986:2184364-2184402 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References