Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 87321..88057 Replicon plasmid unnamed3
Accession NZ_CP055013
Organism Klebsiella quasipneumoniae strain SWHEFF_72

Toxin (Protein)


Gene name tacT Uniprot ID A0A486JQ35
Locus tag HUZ79_RS29425 Protein ID WP_049109282.1
Coordinates 87321..87803 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag HUZ79_RS29430 Protein ID WP_003026799.1
Coordinates 87791..88057 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ79_RS29405 (HUZ79_29325) 83032..83436 - 405 WP_064145647.1 helix-turn-helix domain-containing protein -
HUZ79_RS29410 (HUZ79_29330) 83485..84831 - 1347 WP_182972103.1 ISNCY family transposase -
HUZ79_RS29415 (HUZ79_29335) 85057..85689 + 633 WP_001567369.1 hypothetical protein -
HUZ79_RS29420 (HUZ79_29340) 85718..87121 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
HUZ79_RS29425 (HUZ79_29345) 87321..87803 - 483 WP_049109282.1 GNAT family N-acetyltransferase Toxin
HUZ79_RS29430 (HUZ79_29350) 87791..88057 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
HUZ79_RS29435 (HUZ79_29355) 88343..88450 + 108 Protein_86 transposase -
HUZ79_RS29440 (HUZ79_29360) 88493..89308 - 816 WP_049109278.1 hypothetical protein -
HUZ79_RS29445 (HUZ79_29365) 89586..90509 + 924 WP_049108798.1 IS5 family transposase -
HUZ79_RS29450 (HUZ79_29370) 90855..92090 + 1236 WP_049108797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..167218 167218
- inside IScluster/Tn - - 75918..90509 14591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17336.86 Da        Isoelectric Point: 8.0020

>T160980 WP_049109282.1 NZ_CP055013:c87803-87321 [Klebsiella quasipneumoniae]
VGRITAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCETGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

>T160980 NZ_CP055013:c87803-87321 [Klebsiella quasipneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAAACAGTCCTCGA
TGAATGGCTAAAACACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCGAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACAGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTAAAACTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT160980 WP_003026799.1 NZ_CP055013:c88057-87791 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT160980 NZ_CP055013:c88057-87791 [Klebsiella quasipneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCAGCTGCAGAGATCCTTCA
TAAATCGCGTACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486JQ35

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References