Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 196647..197169 Replicon plasmid unnamed1
Accession NZ_CP055011
Organism Klebsiella quasipneumoniae strain SWHEFF_72

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag HUZ79_RS27260 Protein ID WP_004181778.1
Coordinates 196885..197169 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag HUZ79_RS27255 Protein ID WP_004181777.1
Coordinates 196647..196895 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ79_RS27235 (HUZ79_27195) 191856..192677 - 822 WP_004181772.1 hypothetical protein -
HUZ79_RS27240 (HUZ79_27200) 192739..193092 - 354 WP_004181774.1 hypothetical protein -
HUZ79_RS27245 (HUZ79_27205) 193237..194223 - 987 WP_094965947.1 hypothetical protein -
HUZ79_RS27250 (HUZ79_27210) 194557..196356 - 1800 WP_004181776.1 ATP-dependent helicase -
HUZ79_RS27255 (HUZ79_27215) 196647..196895 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUZ79_RS27260 (HUZ79_27220) 196885..197169 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ79_RS27265 (HUZ79_27225) 197186..197287 - 102 Protein_218 IS200/IS605 family transposase -
HUZ79_RS27270 (HUZ79_27230) 197323..198549 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
HUZ79_RS27275 (HUZ79_27235) 198820..199044 - 225 Protein_220 transposase -
HUZ79_RS27280 (HUZ79_27240) 199123..199551 - 429 WP_077257669.1 IS200/IS605 family transposase -
HUZ79_RS27285 (HUZ79_27245) 199587..200774 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
HUZ79_RS27290 200819..201190 - 372 WP_040209644.1 hypothetical protein -
HUZ79_RS27295 201187..201531 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / catA2 / mph(A) / sul1 / qacE / aadA2 / dfrA12 / aac(3)-IId / aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / ARR-3 / aac(6')-Ib-cr - 1..274085 274085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T160978 WP_004181778.1 NZ_CP055011:196885-197169 [Klebsiella quasipneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T160978 NZ_CP070983:c1894882-1894730 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT160978 WP_004181777.1 NZ_CP055011:196647-196895 [Klebsiella quasipneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT160978 NZ_CP070983:c1895506-1894907 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References