Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 154010..154761 Replicon plasmid unnamed1
Accession NZ_CP055011
Organism Klebsiella quasipneumoniae strain SWHEFF_72

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag HUZ79_RS27005 Protein ID WP_014386536.1
Coordinates 154010..154492 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag HUZ79_RS27010 Protein ID WP_004902250.1
Coordinates 154483..154761 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ79_RS26985 (HUZ79_26945) 150409..151056 - 648 WP_014386537.1 EcsC family protein -
HUZ79_RS26990 (HUZ79_26950) 151083..151838 - 756 WP_004902235.1 DUF2971 domain-containing protein -
HUZ79_RS26995 (HUZ79_26955) 151939..152331 - 393 WP_032442757.1 hypothetical protein -
HUZ79_RS27000 (HUZ79_26960) 152436..152975 - 540 WP_004902239.1 hypothetical protein -
HUZ79_RS27005 (HUZ79_26965) 154010..154492 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
HUZ79_RS27010 (HUZ79_26970) 154483..154761 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
HUZ79_RS27015 (HUZ79_26975) 154880..155092 - 213 WP_004902255.1 hypothetical protein -
HUZ79_RS27020 (HUZ79_26980) 155200..155541 - 342 WP_004902257.1 hypothetical protein -
HUZ79_RS27025 (HUZ79_26985) 156371..156829 - 459 WP_014386535.1 hypothetical protein -
HUZ79_RS27030 (HUZ79_26990) 157482..157937 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
HUZ79_RS27035 (HUZ79_26995) 158009..158374 + 366 WP_001294656.1 mercuric ion transporter MerT -
HUZ79_RS27040 (HUZ79_27000) 158390..158665 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
HUZ79_RS27045 (HUZ79_27005) 158693..159118 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / catA2 / mph(A) / sul1 / qacE / aadA2 / dfrA12 / aac(3)-IId / aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / ARR-3 / aac(6')-Ib-cr - 1..274085 274085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(42-144)

Antitoxin

(10-86)


Sequences


Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T160977 WP_014386536.1 NZ_CP055011:c154492-154010 [Klebsiella quasipneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T160977 NZ_CP070983:c857756-857568 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT160977 WP_004902250.1 NZ_CP055011:c154761-154483 [Klebsiella quasipneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT160977 NZ_CP070983:c858045-857785 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATAACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1


Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References