Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4081926..4082545 Replicon chromosome
Accession NZ_CP055010
Organism Klebsiella quasipneumoniae strain SWHEFF_72

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUZ79_RS20055 Protein ID WP_002892050.1
Coordinates 4082327..4082545 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUZ79_RS20050 Protein ID WP_002892066.1
Coordinates 4081926..4082300 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ79_RS20040 (4077079) 4077079..4078272 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUZ79_RS20045 (4078295) 4078295..4081441 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
HUZ79_RS20050 (4081926) 4081926..4082300 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUZ79_RS20055 (4082327) 4082327..4082545 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HUZ79_RS20060 (4082704) 4082704..4083270 + 567 WP_064187828.1 maltose O-acetyltransferase -
HUZ79_RS20065 (4083242) 4083242..4083364 - 123 WP_032426076.1 hypothetical protein -
HUZ79_RS20070 (4083407) 4083407..4083877 + 471 WP_004204751.1 YlaC family protein -
HUZ79_RS20075 (4083846) 4083846..4085303 - 1458 WP_239605012.1 PLP-dependent aminotransferase family protein -
HUZ79_RS20080 (4085404) 4085404..4086102 + 699 WP_064187826.1 GNAT family protein -
HUZ79_RS20085 (4086099) 4086099..4086239 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUZ79_RS20090 (4086239) 4086239..4086502 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T160974 WP_002892050.1 NZ_CP055010:4082327-4082545 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T160974 NZ_CP070982:5246190-5246600 [Pseudomonas entomophila]
ATGCTCAGGTACATGCTCGATACCAACATCTGCATTTTCACCATCAAGAACAAGCCACAGGTAGTGCGCGAGGCATTCAA
TCGCTACCACGGCCAACTGGCCATCAGCACGGTAACCCTGATGGAGTTGATCTACGGTGCGGAAAAATCCGCCGCGCCGG
AACGTAACCTAGCCATTGTCGAGGGGTTCGCCGCACGGCTCGATGTGCTTGACTACGACATTCAGGGCGCAGCTCACACC
GCGCAGCTACGTGCGGAACTGGCCAAGGCCGGCACGCCCATCGGCCCCTATGACAGAATGATTGCCGGCCACGCCCGCGC
TCGTGGCCTCACGCTGGTGACCAACAACTTGCGCGAGTTCCAGCGTGTTCCGGGGTTGCGTGTGGAAGACTGGGTGACAT
ACCCACGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT160974 WP_002892066.1 NZ_CP055010:4081926-4082300 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT160974 NZ_CP070982:5245960-5246190 [Pseudomonas entomophila]
ATGGAGCAAGGTGCAGTCTTCAAAAGCAACCGCAGCCAGGCTATCCGCATGCCAAAAGCCCTCGCTCTTCCAGAAGACGT
CACCCGCGTGGACATCGTCGCGGTGGGCCGTTCCCGTATCATCTCGCCTGCCGGCGAAAGCTGGGACAGCTGGTTCGAGG
GTGACGATGTGAGTGCGGACTTCATGGCAAGCAGGGAACAGCCAGCCGACCAAGAGCGCGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References