Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2643983..2645571 | Replicon | chromosome |
| Accession | NZ_CP055010 | ||
| Organism | Klebsiella quasipneumoniae strain SWHEFF_72 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | HUZ79_RS12845 | Protein ID | WP_064187239.1 |
| Coordinates | 2643983..2645305 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A2A5MFC9 |
| Locus tag | HUZ79_RS12850 | Protein ID | WP_004205921.1 |
| Coordinates | 2645305..2645571 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ79_RS12810 (2639065) | 2639065..2639283 | + | 219 | WP_002904808.1 | ParD-like family protein | - |
| HUZ79_RS12815 (2639264) | 2639264..2640046 | + | 783 | WP_064187236.1 | type I methionyl aminopeptidase | - |
| HUZ79_RS12820 (2640315) | 2640315..2641430 | + | 1116 | WP_064187237.1 | serine hydrolase domain-containing protein | - |
| HUZ79_RS12825 (2641417) | 2641417..2641761 | + | 345 | WP_004205915.1 | hypothetical protein | - |
| HUZ79_RS12830 (2641790) | 2641790..2642323 | + | 534 | WP_064187238.1 | hypothetical protein | - |
| HUZ79_RS12835 (2642326) | 2642326..2642532 | + | 207 | WP_004205917.1 | helix-turn-helix transcriptional regulator | - |
| HUZ79_RS12840 (2642674) | 2642674..2643966 | + | 1293 | WP_023318214.1 | glycoside hydrolase family 10 protein | - |
| HUZ79_RS12845 (2643983) | 2643983..2645305 | - | 1323 | WP_064187239.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HUZ79_RS12850 (2645305) | 2645305..2645571 | - | 267 | WP_004205921.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| HUZ79_RS12855 (2645854) | 2645854..2646180 | - | 327 | WP_064187240.1 | hydroxyisourate hydrolase | - |
| HUZ79_RS12860 (2646177) | 2646177..2646677 | - | 501 | WP_004205925.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| HUZ79_RS12865 (2646655) | 2646655..2648034 | - | 1380 | WP_017900377.1 | nucleobase:cation symporter-2 family protein | - |
| HUZ79_RS12870 (2648380) | 2648380..2649534 | + | 1155 | WP_004205928.1 | FAD-dependent urate hydroxylase HpxO | - |
| HUZ79_RS12875 (2649515) | 2649515..2650438 | - | 924 | WP_004205929.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49026.36 Da Isoelectric Point: 8.6091
>T160972 WP_064187239.1 NZ_CP055010:c2645305-2643983 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLLAG
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLLAG
Download Length: 1323 bp
>T160972 NZ_CP070982:4701118-4701438 [Pseudomonas entomophila]
ATGCTCTTCAGCGAAACGGTCATCTTCACCAAACGCGTAAAGGAACTGCTCGACGATGAGACTTACCGGCTGCTGCAGGT
TCGTCTCTTGATTGCCCCGGATGCAGGTGACCTCATCGAGGGCACCGGTGGCTTGCGAAAGCTCCGTATCGCAGCGAACG
GGCATGGAAAACGAGGTGGCGCCCGGGTCATCTACTACCACTTCAACGCTGCAGCGCAAATCGCCATGCTCTACATCTAC
CCCAAGAACGAGCAACAGGACTTGTCCACCGAACAGCGCAAGGCACTGAAAGCCGTCATCGAACACTGGAGACACCCATG
A
ATGCTCTTCAGCGAAACGGTCATCTTCACCAAACGCGTAAAGGAACTGCTCGACGATGAGACTTACCGGCTGCTGCAGGT
TCGTCTCTTGATTGCCCCGGATGCAGGTGACCTCATCGAGGGCACCGGTGGCTTGCGAAAGCTCCGTATCGCAGCGAACG
GGCATGGAAAACGAGGTGGCGCCCGGGTCATCTACTACCACTTCAACGCTGCAGCGCAAATCGCCATGCTCTACATCTAC
CCCAAGAACGAGCAACAGGACTTGTCCACCGAACAGCGCAAGGCACTGAAAGCCGTCATCGAACACTGGAGACACCCATG
A
Antitoxin
Download Length: 89 a.a. Molecular weight: 9940.38 Da Isoelectric Point: 7.1997
>AT160972 WP_004205921.1 NZ_CP055010:c2645571-2645305 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW
Download Length: 267 bp
>AT160972 NZ_CP070982:4701435-4701722 [Pseudomonas entomophila]
ATGAGCCGATTTTTCGAAGAGCTGATGCAAAGCGTTGAACAGATGGATGAAATCATCCAGGGGCAACGCCAGCCTTCCCG
CCAGTTCGAAATCGATGCGCTTCAGGTCCGCAACATTCGCAAGCGCACCGGCCTGTCCCAAGTACGCTTCGCCGAGATGA
TCGACGTGCAGGTCGCCACGTTACGCAACTGGGAACAGGGGCGTCGTGAGCCCACCGGCCCCGCCAAGGCATTGCTTCGG
GCACTGCACAATGACCCCGAGCATGTGCTCAAGGCTCTTGCTCACTGA
ATGAGCCGATTTTTCGAAGAGCTGATGCAAAGCGTTGAACAGATGGATGAAATCATCCAGGGGCAACGCCAGCCTTCCCG
CCAGTTCGAAATCGATGCGCTTCAGGTCCGCAACATTCGCAAGCGCACCGGCCTGTCCCAAGTACGCTTCGCCGAGATGA
TCGACGTGCAGGTCGCCACGTTACGCAACTGGGAACAGGGGCGTCGTGAGCCCACCGGCCCCGCCAAGGCATTGCTTCGG
GCACTGCACAATGACCCCGAGCATGTGCTCAAGGCTCTTGCTCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|