Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 823500..824157 Replicon chromosome
Accession NZ_CP055010
Organism Klebsiella quasipneumoniae strain SWHEFF_72

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag HUZ79_RS04030 Protein ID WP_004205323.1
Coordinates 823747..824157 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ79_RS04025 Protein ID WP_002916312.1
Coordinates 823500..823766 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ79_RS04000 (818706) 818706..820139 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
HUZ79_RS04005 (820258) 820258..820986 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
HUZ79_RS04010 (821037) 821037..821348 + 312 WP_045374015.1 N(4)-acetylcytidine aminohydrolase -
HUZ79_RS04015 (821513) 821513..822172 + 660 WP_064187793.1 hemolysin III family protein -
HUZ79_RS04020 (822271) 822271..823254 - 984 WP_048295573.1 tRNA-modifying protein YgfZ -
HUZ79_RS04025 (823500) 823500..823766 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ79_RS04030 (823747) 823747..824157 + 411 WP_004205323.1 protein YgfX Toxin
HUZ79_RS04035 (824164) 824164..824685 - 522 WP_004205324.1 flavodoxin FldB -
HUZ79_RS04040 (824786) 824786..825682 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ79_RS04045 (825705) 825705..826418 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ79_RS04050 (826424) 826424..828157 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T160963 WP_004205323.1 NZ_CP055010:823747-824157 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T160963 NZ_CP070980:c4369611-4369372 [Pseudomonas rhodesiae]
ATGCGTTTTGAATGGGATGAATCAAAAAACAAGGTCAATATTTCCAAGCACGGAATCGATTTCAATGACGTACCCGATAT
TTTTCGCCATCCGATGCTGGCCTTGCGCGATGATCGAGCGGATTATGGGGAAGAGCGTTGGATCTGTATTGGCTGGATAA
AACGGTTAATGGGTGTAGTCGTATACACCGAGCGGTGTGGTGATGTGATTCGTATCATCTCCGCCCGAAAGGCAACTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT160963 WP_002916312.1 NZ_CP055010:823500-823766 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT160963 NZ_CP070980:c4369355-4369107 [Pseudomonas rhodesiae]
ATGACGCAAACATCCAAAACTGATTGGGAGCGCCTGGCCAAGATGAAAGATAAAGAAATCGATACCAGCGACATCCCTGA
GCTGGACGCCGAATTTTTCCGACGTGCAGAGTTACGTGTGCCTGTAAAACAGGCGGTGACTATTCGGCTGGATGCTGACG
TTCTTGAGTGGTTCAAAGGTCAGGGTACGGGCTACCAGACACGGATCAACCAATTGTTGCGTCAATACATGCAGGCCCAT
CAGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References