Detailed information of TA system TA160962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3929700..3931271
• Replicon: chromosome
• Accession: NZ_CP055009
• Organism: Proteus mirabilis strain STIN_74

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HUZ52_RS18165
• Protein ID: WP_063073818.1
• Coordinates: 3929700..3931013 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HUZ52_RS18170
• Protein ID: WP_049203075.1
• Coordinates: 3931014..3931271 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ52_RS18145 (HUZ52_18130)	3924869..3925672	+	804	WP_063073815.1	energy transducer TonB	-
HUZ52_RS18150 (HUZ52_18135)	3925726..3927687	-	1962	WP_063073816.1	insecticidal delta-endotoxin Cry8Ea1 family protein	-
HUZ52_RS18155 (HUZ52_18140)	3927719..3928648	-	930	WP_004246518.1	metallophosphoesterase	-
HUZ52_RS18160 (HUZ52_18145)	3928833..3929297	-	465	WP_063073817.1	DUF1097 domain-containing protein	-
HUZ52_RS18165 (HUZ52_18150)	3929700..3931013	-	1314	WP_063073818.1	type II toxin-antitoxin system HipA family toxin	Toxin
HUZ52_RS18170 (HUZ52_18155)	3931014..3931271	-	258	WP_049203075.1	helix-turn-helix domain-containing protein	Antitoxin
HUZ52_RS18175 (HUZ52_18160)	3931420..3932784	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
HUZ52_RS18180 (HUZ52_18165)	3932922..3934562	-	1641	WP_004246512.1	membrane protein insertase YidC	-
HUZ52_RS18185 (HUZ52_18170)	3934565..3934825	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
HUZ52_RS18190 (HUZ52_18175)	3934789..3935148	-	360	WP_004246510.1	ribonuclease P protein component	-
HUZ52_RS18195 (HUZ52_18180)	3935166..3935309	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49674.86 Da
• Isoelectric Point: 6.7643

>T160962 WP_063073818.1 NZ_CP055009:c3931013-3929700 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLVAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKKYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T160962 NZ_CP070980:3882859-3883146 [Pseudomonas rhodesiae]
ATGGCCGCTGAGTACGAGGTTGAGTGGGATCCGAAGGCACTGAAGGAGTTGCGTAAACTCGACGGAACAATACGCCTCCA
GTTTCTGAAAAAGCTCCAGGAGCGGCAGTCCGGCCCGCGAGTGCCAGGCGATGCGCTTCATGGCATGAAGGACTGCTACA
AGATCAAATTGCGCGGCGCCGGCTACCGACTTGTGTACCGCGTTGAGGATGAGCGAATTGTCATCCTGGTGCTGGCTGTC
GGCAAACGCGAGCGAAGCTCTGTGTATGAGCAGGCGGGGAAGCGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT160962 WP_049203075.1 NZ_CP055009:c3931271-3931014 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT160962 NZ_CP070980:3882582-3882869 [Pseudomonas rhodesiae]
ATGCAAAATATTCTGGCTGATGTGGCCGTCAGCGTATCTGAACTCAAGAAGAACCCCTCCTCCGTCTTGAGCGGCGCCAA
CGGCATGCCTGTGGCTGTGCTGAACCACAACCGCGTTATGGGCTACATGGTTCCAGCAAACGTCTACGAGGCGATGGTTG
AGCGCCTGGACGAACTGGAGCTGGTCCAACTAGTCAAGGCTCGGCTCGATGCTAAAGAAACACCTGTTCGGGTATCTCTG
GACGATCTGATTGGCGAGACAGAGGCAGATATCGCCAATGGCCGCTGA