Detailed information of TA system TA160960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 850695..851716
• Replicon: chromosome
• Accession: NZ_CP055009
• Organism: Proteus mirabilis strain STIN_74

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: HUZ52_RS03880
• Protein ID: WP_004249488.1
• Coordinates: 850695..851264 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: B4F2H3
• Locus tag: HUZ52_RS03885
• Protein ID: WP_004245528.1
• Coordinates: 851264..851716 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ52_RS03875 (HUZ52_03865)	848225..850579	-	2355	WP_017628571.1	DNA polymerase II	-
HUZ52_RS03880 (HUZ52_03870)	850695..851264	-	570	WP_004249488.1	PIN domain-containing protein	Toxin
HUZ52_RS03885 (HUZ52_03875)	851264..851716	-	453	WP_004245528.1	helix-turn-helix domain-containing protein	Antitoxin
HUZ52_RS03890 (HUZ52_03880)	851844..852545	-	702	WP_004245527.1	thiamine ABC transporter ATP-binding protein ThiQ	-
HUZ52_RS03895 (HUZ52_03885)	852538..854118	-	1581	WP_004245526.1	thiamine/thiamine pyrophosphate ABC transporter permease ThiP	-
HUZ52_RS03900 (HUZ52_03890)	854118..855083	-	966	WP_049195511.1	thiamine ABC transporter substrate binding subunit	-
HUZ52_RS03905 (HUZ52_03895)	855400..855930	+	531	WP_004245524.1	RNA pyrophosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-113)

Antitoxin

• SinI-like, DNA-binding domain (80-125)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21600.10 Da
• Isoelectric Point: 7.3470

>T160960 WP_004249488.1 NZ_CP055009:c851264-850695 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Nucleotide

• Length: 570 bp

>T160960 NZ_CP070980:c2550645-2550394 [Pseudomonas rhodesiae]
GTGTCCAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAGCAAATGGCATTTACATGGCCCGAACTCGTCACGCTGCT
GCGTCGCCTGGGCTACACACAGATCGAAGGGGCTGGAAGCCGCGTCAAGTTCGACAGTGGCGACCCCACTGCCATGATCA
CGCTGCACAAGCCTCACCCTGGCAACGAACTGAAGCACTACATTCGACGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16700.15 Da
• Isoelectric Point: 5.7723

>AT160960 WP_004245528.1 NZ_CP055009:c851716-851264 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Nucleotide

• Length: 453 bp

>AT160960 NZ_CP070980:c2550397-2550035 [Pseudomonas rhodesiae]
GTGAACAACCAACTCAAACACAAAGGCTACATCGGCTCTATCGAGGCCAGCCTTGAAGACAACTGCCTGTTCGGCAAGAT
CTTGTTCATCAAGGCGCTGATCAGCTACGAAGGAAAAACCGTCGCTGATTTGGATGCCGCTTTTCAGGCGGCCGTGGACG
ACTATCTCGTGACGTGCCAGAACCTTGGTCAAACCCCGGAAAAGCCATGCAAGGGCTCTTTCAATGTGCGGGTTGGACAT
GACCTGCATTTGGCTGCGGCGCTGGCGGCGACCCGCAAGAAAGTCACGCTCAATGACCTGACGCGTCAGGCGCTGAGTGA
GTTCCTGCAACATCACTTCGCAGAACTTCACCCCAGCGCATAG

Structures

Antitoxin

• AlphaFold DB: B4F2H3