Detailed information of TA system TA160959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 403716..404415
• Replicon: chromosome
• Accession: NZ_CP055009
• Organism: Proteus mirabilis strain STIN_74

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUZ52_RS01940
• Protein ID: WP_017628658.1
• Coordinates: 404029..404415 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: HUZ52_RS01935
• Protein ID: WP_004246828.1
• Coordinates: 403716..404036 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ52_RS01905 (HUZ52_01895)	398847..399122	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
HUZ52_RS01910 (HUZ52_01900)	399177..399800	-	624	WP_004246821.1	guanylate kinase	-
HUZ52_RS01915 (HUZ52_01905)	400101..400718	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
HUZ52_RS01920 (HUZ52_01910)	400855..402141	+	1287	WP_063073863.1	DUF3748 domain-containing protein	-
HUZ52_RS01925 (HUZ52_01915)	402356..403240	+	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
HUZ52_RS01930 (HUZ52_01920)	403233..403667	+	435	WP_004246827.1	hypothetical protein	-
HUZ52_RS01935 (HUZ52_01925)	403716..404036	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
HUZ52_RS01940 (HUZ52_01930)	404029..404415	-	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUZ52_RS01945 (HUZ52_01935)	404577..406649	-	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
HUZ52_RS01950 (HUZ52_01940)	406659..407564	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
HUZ52_RS01955 (HUZ52_01945)	407815..408396	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T160959 WP_017628658.1 NZ_CP055009:c404415-404029 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T160959 NZ_CP070980:c891193-890891 [Pseudomonas rhodesiae]
ATGATTCAATTTAAGAAGTCAAAACACTTTCAAGAATGGCTTGATTCGTTACGCAGTAAACCCGCGCGAGCACGCGTACT
GGCGAGGTTGGATAACGCGCAATGGGGCAACTTTGGAGATTGCGAAGCGCTCGGAAATGGCGTTTTTGAAATGCGCATCC
ACTATGGCCCTGGCTACAGGGTTTATTTCACTCGCAGAGGCGAGGTGGTTTATCTGCTGTTGATCGGAGGCGACAAATCA
ACGCAGAAACGTGACATTCAGCGCGCTAAACAAATTGCAGAAGACTTTGAGAAAAAGGAGTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT160959 WP_004246828.1 NZ_CP055009:c404036-403716 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT160959 NZ_CP070980:c890887-890600 [Pseudomonas rhodesiae]
ATGAATGAATTCACTGACTTCGATGTGGCAGAGCACCTAAGAACGCCCGAAGATATGGCCGAATATCTTGAGGCATGCTT
CGAAGAAGATGCGGGCGACGGCGTGCTGATTCGTTCGGCGCTCAATAACATCGCCCGCGCCCAAGGCATGACCCAAGTAG
CCCGCGACGCGGGCCTCGGCAGAGAAAGTCTGTACAAAGCCCTCTCCAGCAGTGGCAATCCCGAGTTCGCGACTATCATG
AAAGTCATGAAAGCGTTGGGCCTCAAGCTGCACGCCACAGTGATCTGA

Structures

Antitoxin

• AlphaFold DB: B4EZ97