Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 11798..12399 Replicon chromosome
Accession NZ_CP055009
Organism Proteus mirabilis strain STIN_74

Toxin (Protein)


Gene name doc Uniprot ID A0A7D6AHD8
Locus tag HUZ52_RS00050 Protein ID WP_063073825.1
Coordinates 11798..12181 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7D5W489
Locus tag HUZ52_RS00055 Protein ID WP_063073826.1
Coordinates 12178..12399 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ52_RS00030 (HUZ52_00030) 7730..8293 + 564 WP_063073823.1 rRNA adenine N-6-methyltransferase family protein -
HUZ52_RS00035 (HUZ52_00035) 8569..9468 + 900 WP_063073824.1 N-acetylmuramic acid 6-phosphate etherase -
HUZ52_RS00040 (HUZ52_00040) 9825..11063 - 1239 WP_004246499.1 HipA domain-containing protein -
HUZ52_RS00045 (HUZ52_00045) 11076..11390 - 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
HUZ52_RS00050 (HUZ52_00050) 11798..12181 - 384 WP_063073825.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HUZ52_RS00055 (HUZ52_00055) 12178..12399 - 222 WP_063073826.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUZ52_RS00060 (HUZ52_00060) 12644..13507 - 864 WP_063073829.1 YicC/YloC family endoribonuclease -
HUZ52_RS00065 (HUZ52_00065) 13634..14350 + 717 WP_004249946.1 ribonuclease PH -
HUZ52_RS00070 (HUZ52_00070) 14432..15076 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
HUZ52_RS00075 (HUZ52_00075) 15395..16000 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
HUZ52_RS00080 (HUZ52_00080) 16120..16578 - 459 WP_239619347.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14485.56 Da        Isoelectric Point: 8.5126

>T160957 WP_063073825.1 NZ_CP055009:c12181-11798 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVEQLAKHLQNLVEKTN

Download         Length: 384 bp

>T160957 NZ_CP070978:3171854-3172273 [Burkholderia pyrrocinia]
ATGATCCTTGTCGATACGAACGTCATTTCCGAACCGCTGCGACGCGAGCCGAGCGCGGCCGTGATCGAGTGGCTCGACGC
CCAGAACATCGAGACACTATTTCTTGCCGCGATCAGTCTCGCGGAGATGCGATTCGGCGTGGCGATATTGCCGGAAGGGC
GAAGGCGCGAGTGGCTGCATCAAAGCATCGAACAGCGTGTCGTGCCGCTGTTTCGAGGCCGGATCCTGCCGTTCGACGAC
GCAGCGAGCAATGCGTACGCGAGCATTCGAGCGCGGGCCCGTGTCACTGGAAGCGCGATCGCGCCTGTCGATGGTTTTAT
CGCCGCCACGGCCGAGGCGAACGGCCTGATCGTGGCCACGCGCGACGTCGCACCGTTCGAGGCGATGGGGCTTCGCGTGA
TCGATCCGTGGGGGCGGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8290.25 Da        Isoelectric Point: 5.5667

>AT160957 WP_063073826.1 NZ_CP055009:c12399-12178 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNTKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT160957 NZ_CP070978:3171618-3171857 [Burkholderia pyrrocinia]
ATGCCGGTGATCACCGTTCGAAATTTGCCCGATGAAGTGCATCGCGCACTTCGGATTCGCGCGGCCCAGCACGGGCGCAG
CACCGAAGCCGAGGTACGTGACATTCTGGAACAGGCTGTCCTGCCAGGTGGGCGGCTCAAGCTGGGAACGTTGCTGGCGG
AAATCGGGCGGGAGGCTGGGGGAGTCGATTTCGACGCTCGGCGCGACAAGACGTCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6AHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5W489

References