Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4963426..4965107 Replicon chromosome
Accession NZ_CP055005
Organism Klebsiella pneumoniae strain STIN_77

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag HUZ53_RS24355 Protein ID WP_002885155.1
Coordinates 4963426..4964343 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag HUZ53_RS24360 Protein ID WP_004151732.1
Coordinates 4964349..4965107 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ53_RS24335 (HUZ53_24295) 4958732..4960252 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
HUZ53_RS24340 (HUZ53_24300) 4960249..4961247 + 999 WP_002885172.1 ribose ABC transporter permease -
HUZ53_RS24345 (HUZ53_24305) 4961278..4962219 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
HUZ53_RS24350 (HUZ53_24310) 4962294..4963301 + 1008 WP_004151731.1 carbohydrate kinase family protein -
HUZ53_RS24355 (HUZ53_24315) 4963426..4964343 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HUZ53_RS24360 (HUZ53_24320) 4964349..4965107 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
HUZ53_RS24365 (HUZ53_24325) 4965193..4965921 - 729 WP_002885152.1 response regulator transcription factor -
HUZ53_RS24370 (HUZ53_24330) 4966194..4968341 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
HUZ53_RS24375 (HUZ53_24335) 4968571..4969257 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T160951 WP_002885155.1 NZ_CP055005:c4964343-4963426 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T160951 NZ_CP070978:70997-71893 [Burkholderia pyrrocinia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCAGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTATCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAGCGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGCGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGTGCGCCCGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTTGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGAGGATGCCCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGTTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGTTTTCGCGGCCGCACGGCGGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCTGCCGCATGCGAGCGGATCGCCGCGGCCGCGCATGTCGGGCTGCAGGTGATTCCGCA
GGCAGGCCATGCCGGTTACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGATACGC
AGCGAGGGCTGGGATGA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT160951 WP_004151732.1 NZ_CP055005:c4965107-4964349 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT160951 NZ_CP070978:71973-72827 [Burkholderia pyrrocinia]
ATGAGTGAACCGCTGCAACAAGAAGCCGAAAACGGCAAGGCCGAGGCCGGCTACGTGGTGCCGGGCCTCGAGCGCGGGCT
GCGGATTCTCGCCGAGTTCTCGCCGCGCGAGCCCGTGCTGGGCGCGCCCGAGTTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAGTCGCTCGGCTTCCTCGAGCGGGCGGACAAGGATCGCAACTACAAGCTT
GGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGAGAG
CCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAAGCGCAGA
GCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGCTTGCCCGCGCATGCGACGACGCACGGCCATGTG
CTGATGGGCGACCTGTCGCTGAAGGAGCTGCGCGCGCTGTATCCGCAAGGCACGCTGAACCGGATGACGAACGCGACGCC
GGAGACGGTCGATGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTATGGCGTCAGCAACTCGTCGTTCGAGC
GCGGCATCTCGGTGGTCACGGCGCCCGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGG
CCGGAGATCGATGCGGCGCTGATCGCGGACGGGTTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCGGCT
CAATTACCGCTCGGATGACGAGCACACGTTTCTTAAGGCGTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References