Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4266999..4267690 Replicon chromosome
Accession NZ_CP055005
Organism Klebsiella pneumoniae strain STIN_77

Toxin (Protein)


Gene name ypjF Uniprot ID A0A2A3UTQ9
Locus tag HUZ53_RS21025 Protein ID WP_001094399.1
Coordinates 4267322..4267690 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HUZ53_RS21020 Protein ID WP_001405555.1
Coordinates 4266999..4267301 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ53_RS20990 (HUZ53_20955) 4263730..4263963 + 234 WP_001117568.1 DUF905 family protein -
HUZ53_RS20995 (HUZ53_20960) 4264054..4264872 + 819 WP_097586124.1 DUF932 domain-containing protein -
HUZ53_RS21000 (HUZ53_20965) 4264963..4265448 + 486 WP_000214318.1 antirestriction protein -
HUZ53_RS21005 (HUZ53_20970) 4265463..4265939 + 477 WP_001186742.1 RadC family protein -
HUZ53_RS21010 (HUZ53_20975) 4266008..4266229 + 222 WP_000692315.1 DUF987 domain-containing protein -
HUZ53_RS21015 (HUZ53_20980) 4266248..4266892 + 645 WP_000086755.1 hypothetical protein -
HUZ53_RS21020 (HUZ53_20985) 4266999..4267301 + 303 WP_001405555.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ53_RS21025 (HUZ53_20990) 4267322..4267690 + 369 WP_001094399.1 TA system toxin CbtA family protein Toxin
HUZ53_RS21030 (HUZ53_20995) 4267779..4268456 + 678 WP_001682408.1 IS66-like element accessory protein TnpA -
HUZ53_RS21035 (HUZ53_21000) 4268456..4268803 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
HUZ53_RS21040 (HUZ53_21005) 4268823..4270394 + 1572 WP_000381395.1 IS66-like element ISCro1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4252230..4268456 16226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(2-99)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13568.73 Da        Isoelectric Point: 7.7465

>T160948 WP_001094399.1 NZ_CP055005:4267322-4267690 [Klebsiella pneumoniae]
MNTLPATISPAAKPCPSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTATDILQARKACGLMSRCSYRDVSNIVLSRSRL

Download         Length: 369 bp

>T160948 NZ_CP070976:c2259137-2258961 [Bacillus halotolerans]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTACACGTAAGCGACTCCGTAGCAAGAGGCAACGCA
AACGTATACGCAGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11132.66 Da        Isoelectric Point: 6.0454

>AT160948 WP_001405555.1 NZ_CP055005:4266999-4267301 [Klebsiella pneumoniae]
VGLPYTVTPCSGTRLVQEGNRLYYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCFTLYHNGFTC
EADTLGSCGYVYIAIYPTQL

Download         Length: 303 bp

>AT160948 NZ_CP070976:2259078-2259178 [Bacillus halotolerans]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A3UTQ9

Antitoxin

Source ID Structure

References