Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2679871..2681459 Replicon chromosome
Accession NZ_CP055005
Organism Klebsiella pneumoniae strain STIN_77

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag HUZ53_RS13150 Protein ID WP_004199851.1
Coordinates 2679871..2681193 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HUZ53_RS13155 Protein ID WP_002904790.1
Coordinates 2681193..2681459 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ53_RS13135 (HUZ53_13110) 2674936..2677437 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
HUZ53_RS13140 (HUZ53_13115) 2677425..2678429 + 1005 WP_004199852.1 fimbrial protein -
HUZ53_RS13145 (HUZ53_13120) 2678562..2679854 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HUZ53_RS13150 (HUZ53_13125) 2679871..2681193 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
HUZ53_RS13155 (HUZ53_13130) 2681193..2681459 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUZ53_RS13160 (HUZ53_13135) 2681725..2682051 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HUZ53_RS13165 (HUZ53_13140) 2682048..2682548 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HUZ53_RS13170 (HUZ53_13145) 2682526..2683905 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
HUZ53_RS13175 (HUZ53_13150) 2684251..2685405 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HUZ53_RS13180 (HUZ53_13155) 2685386..2686309 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T160946 WP_004199851.1 NZ_CP055005:c2681193-2679871 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T160946 NZ_CP070976:c2258942-2258691 [Bacillus halotolerans]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGTAAACATGAAACGATTCTCTCTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTGATGTTTCAACTCATTAAGGATTACTTCAGCAGCGAAGCACAAACACTAA
TCAATACAATATTTGTAGTCACATGTATCATTATCTTTCTGATATGGATCATCTATTTTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT160946 WP_002904790.1 NZ_CP055005:c2681459-2681193 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT160946 NZ_CP070976:2258920-2259020 [Bacillus halotolerans]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTGGTACTCATCTGCGTATACGTTTGCGTTGCCTCTTGCTACGGAG
TCGCTTACGTGTACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References