Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 13139..13782 Replicon plasmid unnamed1
Accession NZ_CP055004
Organism Klebsiella pneumoniae strain STIN_79

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag HUZ54_RS25925 Protein ID WP_000754566.1
Coordinates 13139..13555 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag HUZ54_RS25930 Protein ID WP_001261276.1
Coordinates 13552..13782 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ54_RS25895 (HUZ54_25850) 8305..9165 + 861 WP_000027057.1 broad-spectrum class A beta-lactamase TEM-1 -
HUZ54_RS25900 (HUZ54_25855) 9313..9834 + 522 Protein_9 Tn3 family transposase -
HUZ54_RS25905 (HUZ54_25860) 9997..10080 - 84 Protein_10 SOS response-associated peptidase -
HUZ54_RS25910 (HUZ54_25865) 10600..10701 + 102 Protein_11 Tn3 family transposase -
HUZ54_RS25915 (HUZ54_25870) 10721..11797 - 1077 WP_000227969.1 IS110 family transposase -
HUZ54_RS25920 (HUZ54_25875) 12079..12935 - 857 Protein_13 IS3-like element ISEc15 family transposase -
HUZ54_RS25925 (HUZ54_25880) 13139..13555 - 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
HUZ54_RS25930 (HUZ54_25885) 13552..13782 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HUZ54_RS25935 (HUZ54_25890) 14356..14706 + 351 WP_000493378.1 hypothetical protein -
HUZ54_RS25940 (HUZ54_25895) 14757..15500 + 744 WP_000129823.1 hypothetical protein -
HUZ54_RS25945 (HUZ54_25900) 15497..16273 + 777 WP_000015958.1 site-specific integrase -
HUZ54_RS25950 (HUZ54_25905) 16331..16588 - 258 WP_000764642.1 hypothetical protein -
HUZ54_RS25955 (HUZ54_25910) 16717..16821 - 105 WP_032409716.1 hypothetical protein -
HUZ54_RS25960 (HUZ54_25915) 17351..18217 + 867 WP_004118283.1 replication initiation protein -
HUZ54_RS25965 (HUZ54_25920) 18394..18663 - 270 WP_000339857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(3')-Ia / blaTEM-1A / aph(6)-Id / floR / tet(A) / qnrS1 / sul1 / qacE / aadA2 / dfrA12 - 1..58253 58253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T160933 WP_000754566.1 NZ_CP055004:c13555-13139 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

>T160933 NZ_CP070970:c3362011-3361526 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT160933 WP_001261276.1 NZ_CP055004:c13782-13552 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT160933 NZ_CP070970:c3362301-3362008 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References