Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4659159..4659862 Replicon chromosome
Accession NZ_CP055003
Organism Klebsiella pneumoniae strain STIN_79

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HUZ54_RS22850 Protein ID WP_032728834.1
Coordinates 4659159..4659500 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HUZ54_RS22855 Protein ID WP_062729743.1
Coordinates 4659521..4659862 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ54_RS22835 (HUZ54_22790) 4654644..4656131 + 1488 WP_021441098.1 HEPN domain-containing protein -
HUZ54_RS22845 (HUZ54_22800) 4657893..4658900 - 1008 WP_073511318.1 restriction endonuclease -
HUZ54_RS22850 (HUZ54_22805) 4659159..4659500 - 342 WP_032728834.1 TA system toxin CbtA family protein Toxin
HUZ54_RS22855 (HUZ54_22810) 4659521..4659862 - 342 WP_062729743.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ54_RS22860 (HUZ54_22815) 4659873..4660412 - 540 WP_062729744.1 DNA repair protein RadC -
HUZ54_RS22865 (HUZ54_22820) 4660425..4660868 - 444 WP_049594271.1 antirestriction protein -
HUZ54_RS22870 (HUZ54_22825) 4660899..4661720 - 822 WP_073511317.1 DUF932 domain-containing protein -
HUZ54_RS22875 (HUZ54_22830) 4661793..4662050 - 258 WP_073511316.1 DUF905 domain-containing protein -
HUZ54_RS22880 (HUZ54_22835) 4662122..4662571 - 450 WP_015699704.1 IrmA family protein -
HUZ54_RS22885 (HUZ54_22840) 4662568..4663020 - 453 WP_062933992.1 hypothetical protein -
HUZ54_RS22890 (HUZ54_22845) 4663057..4663626 - 570 WP_073511315.1 hypothetical protein -
HUZ54_RS22895 (HUZ54_22850) 4663626..4664330 - 705 WP_073511314.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4645655..4689775 44120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12777.71 Da        Isoelectric Point: 7.1648

>T160929 WP_032728834.1 NZ_CP055003:c4659500-4659159 [Klebsiella pneumoniae]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGITLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

>T160929 NZ_CP070970:c38148-37930 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12747.39 Da        Isoelectric Point: 6.6214

>AT160929 WP_062729743.1 NZ_CP055003:c4659862-4659521 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCFTLYHNGFSCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp

>AT160929 NZ_CP070970:c38549-38175 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References