Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4618711..4619521 Replicon chromosome
Accession NZ_CP055003
Organism Klebsiella pneumoniae strain STIN_79

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag HUZ54_RS22665 Protein ID WP_004178461.1
Coordinates 4618711..4619244 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag HUZ54_RS22670 Protein ID WP_002887278.1
Coordinates 4619255..4619521 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ54_RS22660 (HUZ54_22615) 4617542..4618663 + 1122 WP_021441121.1 cupin domain-containing protein -
HUZ54_RS22665 (HUZ54_22620) 4618711..4619244 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
HUZ54_RS22670 (HUZ54_22625) 4619255..4619521 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
HUZ54_RS22675 (HUZ54_22630) 4619624..4621057 - 1434 WP_021441120.1 Cu(+)/Ag(+) sensor histidine kinase -
HUZ54_RS22680 (HUZ54_22635) 4621047..4621730 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
HUZ54_RS22685 (HUZ54_22640) 4621903..4623288 + 1386 WP_038806759.1 efflux transporter outer membrane subunit -
HUZ54_RS22690 (HUZ54_22645) 4623306..4623650 + 345 WP_021441118.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T160928 WP_004178461.1 NZ_CP055003:c4619244-4618711 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T160928 NZ_CP070969:1115428-1115778 [Paenibacillus sp. TB2019]
TTGATCGTTAAACGCGGCGACGTTTTTTTTGCCGACCTTTCGCCGGTAGTAGGTTCTGAACAAGGCGGAGTAAGGCCGGT
ACTGGTCATACAGAACGATATTGGCAACCGATTCAGCCCGACGGTCATTGTGGCGGCGATTACCGCCCAGATCCAGAAGG
CCAAACTGCCGACGCATGTGGAAATTGATGCGGCTGCTCATGGCTTTGACCGGGATTCCGTCATTTTGCTGGAGCAGGTC
CGGACGATTGACAAACAACGCTTAACCGATAAGATCACCCATCTTGATGATGAAACAATGAAAAAGGTGGATGATTCGCT
GCAAATCAGCCTGGGCCTGATCGATTTCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT160928 WP_002887278.1 NZ_CP055003:c4619521-4619255 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT160928 NZ_CP070969:1115173-1115424 [Paenibacillus sp. TB2019]
ATGATCAGTTTGCCCGATCATCTCTTGCAGGAAGTGGATGGTATCGCTCAATTGGAGAACTCTAACCGGAGTGAATTGAT
CAGGCAGGCTATGAAGCTGTATTTAACGGAACGGAAGAAACGTACGATCCGGGAGTCAATGCAGCGGGGATACATGGAGA
TGGCTAAGATCAATTTGACAATGGCAAGCGAGGCGTTTCTCGCAGAGGAAGATGCAGACAGTACTCTTGGCCGCTTAGTA
AGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References