Detailed information of TA system TA160926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2609934..2611522
• Replicon: chromosome
• Accession: NZ_CP055003
• Organism: Klebsiella pneumoniae strain STIN_79

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A6T928
• Locus tag: HUZ54_RS12890
• Protein ID: WP_004176197.1
• Coordinates: 2609934..2611256 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HUZ54_RS12895
• Protein ID: WP_032417111.1
• Coordinates: 2611256..2611522 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ54_RS12875 (HUZ54_12845)	2604990..2607491	+	2502	WP_016831617.1	fimbria/pilus outer membrane usher protein	-
HUZ54_RS12880 (HUZ54_12850)	2607479..2608483	+	1005	WP_004176196.1	fimbrial protein	-
HUZ54_RS12885 (HUZ54_12855)	2608625..2609917	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HUZ54_RS12890 (HUZ54_12860)	2609934..2611256	-	1323	WP_004176197.1	type II toxin-antitoxin system HipA family toxin	Toxin
HUZ54_RS12895 (HUZ54_12865)	2611256..2611522	-	267	WP_032417111.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HUZ54_RS12900 (HUZ54_12870)	2611787..2612113	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
HUZ54_RS12905 (HUZ54_12875)	2612110..2612610	-	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HUZ54_RS12910 (HUZ54_12880)	2612588..2613967	-	1380	WP_021440115.1	nucleobase:cation symporter-2 family protein	-
HUZ54_RS12915 (HUZ54_12885)	2614313..2615467	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HUZ54_RS12920 (HUZ54_12890)	2615448..2616371	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.41 Da
• Isoelectric Point: 7.5357

>T160926 WP_004176197.1 NZ_CP055003:c2611256-2609934 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T160926 NZ_CP070968:3180016-3180351 [Brevundimonas sp. CS1]
ATGCCGGACTTTGAGCGCGGCGACGTCGTCCGCGTCCCCTTCCCCTACACCGATCGCAGCACCCGACAGCATCGCCCGGC
CCTGGTCGTTTCCGATGGGCCGCTAGGCGATGATGGCAGGCTGGTGTGGGTCGTGATGATCACCAGCGCCGACAACCGAT
CTTGGGCGGACGACGTACCGCTGGGCGACAGCTATTCCGAAGCCGGCCTGCCCGCCCCGTCCGTCGTTCGACCCGCGAAG
ATTGCGACAATAGACCCTGCTGTCGCAACTCGCCTCGGCCGTATCGACGCCGAGCGTCTGGCGCGGACAATGACTGTGAT
GCGCGCCAACCTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9926.32 Da
• Isoelectric Point: 8.5912

>AT160926 WP_032417111.1 NZ_CP055003:c2611522-2611256 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT160926 NZ_CP070968:3179814-3180029 [Brevundimonas sp. CS1]
ATGATCAAGAGCCGCCTGACATCCAAGGCCCAGACGACCATCCCTCAGGCGGTGCGCGCCGCGCTGAGCCTGCAGGACGG
CGACGAGTTGCAATATGATCTGGACGGCGACCGAGTGATCCTGCGCAAGGTCCGCAGGGCGCCGGTCGAAGACCCCTTCG
CGGCGTTCGACGAATGGGACAGCGACGCGGACCGCAAGGCCTATGCCGGACTTTGA

Structures

Toxin

• AlphaFold DB: A6T928