Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4278156..4278954 Replicon chromosome
Accession NZ_CP055000
Organism Shigella flexneri strain STIN_80

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag HUZ55_RS21290 Protein ID WP_000854735.1
Coordinates 4278577..4278954 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag HUZ55_RS21285 Protein ID WP_001285415.1
Coordinates 4278156..4278530 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ55_RS21250 (4274087) 4274087..4274767 + 681 WP_001282919.1 WYL domain-containing protein -
HUZ55_RS21255 (4274915) 4274915..4275592 + 678 WP_001097302.1 hypothetical protein -
HUZ55_RS21260 (4275598) 4275598..4275831 + 234 WP_001278287.1 DUF905 family protein -
HUZ55_RS21265 (4275921) 4275921..4276739 + 819 WP_001175148.1 DUF932 domain-containing protein -
HUZ55_RS21270 (4276821) 4276821..4277300 + 480 WP_000844100.1 antirestriction protein -
HUZ55_RS21275 (4277316) 4277316..4277792 + 477 WP_001366855.1 RadC family protein -
HUZ55_RS21280 (4277855) 4277855..4278076 + 222 WP_000692309.1 DUF987 domain-containing protein -
HUZ55_RS21285 (4278156) 4278156..4278530 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ55_RS21290 (4278577) 4278577..4278954 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
HUZ55_RS21295 (4278951) 4278951..4279439 + 489 WP_000761676.1 DUF5983 family protein -
HUZ55_RS21300 (4279451) 4279451..4279648 + 198 WP_000839291.1 DUF957 domain-containing protein -
HUZ55_RS21305 (4279733) 4279733..4280599 + 867 WP_001280433.1 DUF4942 domain-containing protein -
HUZ55_RS21310 (4280671) 4280671..4280934 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
HUZ55_RS21315 (4280931) 4280931..4281257 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUZ55_RS21320 (4282139) 4282139..4283677 + 1539 Protein_4188 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T160903 WP_000854735.1 NZ_CP055000:4278577-4278954 [Shigella flexneri]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T160903 NZ_CP070962:c3286368-3285970 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT160903 WP_001285415.1 NZ_CP055000:4278156-4278530 [Shigella flexneri]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT160903 NZ_CP070962:c3286664-3286371 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References