Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4637350..4637866 Replicon chromosome
Accession NZ_CP054997
Organism Klebsiella pneumoniae strain STIN_84

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag HUZ56_RS22390 Protein ID WP_009309309.1
Coordinates 4637350..4637634 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ56_RS22395 Protein ID WP_002886901.1
Coordinates 4637624..4637866 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ56_RS22365 (HUZ56_22320) 4632825..4633088 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HUZ56_RS22370 (HUZ56_22325) 4633218..4633391 + 174 WP_002886906.1 hypothetical protein -
HUZ56_RS22375 (HUZ56_22330) 4633394..4634137 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ56_RS22380 (HUZ56_22335) 4634494..4636632 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ56_RS22385 (HUZ56_22340) 4636882..4637346 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ56_RS22390 (HUZ56_22345) 4637350..4637634 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ56_RS22395 (HUZ56_22350) 4637624..4637866 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ56_RS22400 (HUZ56_22355) 4637944..4639854 - 1911 WP_004152270.1 PRD domain-containing protein -
HUZ56_RS22405 (HUZ56_22360) 4639877..4641031 - 1155 WP_002886900.1 lactonase family protein -
HUZ56_RS22410 (HUZ56_22365) 4641098..4641838 - 741 WP_060175498.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T160873 WP_009309309.1 NZ_CP054997:c4637634-4637350 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T160873 NZ_CP070959:c1225794-1225309 [Thiomicrospira microaerophila]
TTGGCAAGCCTAATTTCCGCACCGGCGGTGTTAAGTGACCAACATGATTTAGGCTCATTTTGTTGTGGGCATGACAGGTT
GGATTATTGGTTAAAAAGGGAAGCCATGCGCAACCAAAAAAATCATGGTAGTAAAACCTTTGTGATTACTTGCGCGGATC
AAGTCGTTGGTTATTATGCCTTGGCCGCTGGAAGTGTGGAGCGCCAAGAGGTCAGCAAAACCAACGCTCGAAATATGCCG
GATACTATTCCGGTGATTATGCTGGGGCGGTTGGCGATGGATAAAACGATGCAAGGAAAAGCACTGCTAAAGGACGCGTT
ATTTCGAAGCCTGAATGTCGCGAATGAAATTGCCGTTAAAGCCGCTTTGGTGCATGCCATTTATGATCAAGCGTGTAGGT
TTTATCAAAATTTCGGCTTTAAACCATTACCCGGCACTGAGCGAACCCTCATGCTCCCCATCAGCCATATCCAAGCCGCG
CTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT160873 WP_002886901.1 NZ_CP054997:c4637866-4637624 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT160873 NZ_CP070959:c1226048-1225782 [Thiomicrospira microaerophila]
ATGTTAGCAAAAGCCCCAATTAATATGCGCGTGTTACCAGAGCAAAAAGCACTGATTTCAAAAGCAGCAGAAATACTGAG
TATGGATAGAACAACGTTCATTCTGAATGTGGCGTGCCGTGAAGCTGAAAATGTGTTGCTAGATCAGCGTTTATTTCTGC
TCAATCAGAATGATTACAATGCGTTTGAAACCGCGTTAATGGCGACGCCAAAACCCAATGCGCTACTGAAGAAGCTGTTG
TCGGAACCATCGCCTTGGCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References