Detailed information of TA system TA160870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2601051..2602639
• Replicon: chromosome
• Accession: NZ_CP054997
• Organism: Klebsiella pneumoniae strain STIN_84

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HUZ56_RS12695
• Protein ID: WP_064159736.1
• Coordinates: 2601051..2602373 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HUZ56_RS12700
• Protein ID: WP_002904790.1
• Coordinates: 2602373..2602639 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ56_RS12680 (HUZ56_12645)	2596107..2598608	+	2502	WP_086519589.1	fimbria/pilus outer membrane usher protein	-
HUZ56_RS12685 (HUZ56_12650)	2598596..2599600	+	1005	WP_004184029.1	fimbrial protein	-
HUZ56_RS12690 (HUZ56_12655)	2599742..2601034	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HUZ56_RS12695 (HUZ56_12660)	2601051..2602373	-	1323	WP_064159736.1	type II toxin-antitoxin system HipA family toxin	Toxin
HUZ56_RS12700 (HUZ56_12665)	2602373..2602639	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HUZ56_RS12705 (HUZ56_12670)	2603267..2603593	-	327	WP_086519588.1	hydroxyisourate hydrolase	-
HUZ56_RS12710 (HUZ56_12675)	2603590..2604090	-	501	WP_023282573.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HUZ56_RS12715 (HUZ56_12680)	2604068..2605447	-	1380	WP_086519587.1	nucleobase:cation symporter-2 family protein	-
HUZ56_RS12720 (HUZ56_12685)	2605793..2606947	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49187.51 Da
• Isoelectric Point: 7.5357

>T160870 WP_064159736.1 NZ_CP054997:c2602373-2601051 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSLRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T160870 NZ_CP070959:1137395-1137574 [Thiomicrospira microaerophila]
TTGAAAAGCAGTGAACTCAGGAAGTGGTTAATCGAGCAAGGCGCTCGGTTTGAAAAGGCAAAAGGCTCCCACTTCAAAGT
TTACCTAGGTGACAAAATGACGATTTTCCCCTTCCATGGCGCAAAAGAAATGGCGACCGGAACGGTAAATAAGATTTTAA
AAGATCTAGGACTGAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT160870 WP_002904790.1 NZ_CP054997:c2602639-2602373 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT160870 NZ_CP070959:1137641-1138051 [Thiomicrospira microaerophila]
ATGCAATATGCAATGAACCTTGAAAAAGAAGGCGATATTTTAATCGTCACCTTTCCCGATATACCGGAAGCATTAACCGA
GGTACATAAAGGCGCTGATTTGCAGGCGATGGCATTAGATGCGCTTGAATCTGCATTGGATTTTTATCCCGAAACCAAAC
GCCCGATTCCACTACCCTCAAAAACTAACGCCGCCAATGGCTTGCTGATTCCAACCGCTTTAGCGGCCAAAATTCACCTC
TACAATGCGTGGTTGGCATCCGGCCAATCTAAAACCGAATTAGCGACCAAGGTAGGCGTTGCGCCGTCTAACTTGAACCG
ATTATTTGATTTCAAATATCGCTCAAAAATCGAAGCCATTGAAGCCGCCTTGCATGCTTTGGGCAAACACTTTGAACTAC
AAGTAGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8