Detailed information of TA system TA160861

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1162144..1162927
• Replicon: chromosome
• Accession: NZ_CP054997
• Organism: Klebsiella pneumoniae strain STIN_84

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HUZ56_RS05725
• Protein ID: WP_004114636.1
• Coordinates: 1162144..1162518 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HUZ56_RS05730
• Protein ID: WP_004114633.1
• Coordinates: 1162568..1162927 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ56_RS05705 (HUZ56_05695)	1158087..1158989	-	903	WP_004114645.1	bacteriophage abortive infection AbiH family protein	-
HUZ56_RS05710 (HUZ56_05700)	1159076..1159993	+	918	WP_004114644.1	hypothetical protein	-
HUZ56_RS05715 (HUZ56_05705)	1160616..1161605	+	990	WP_004114642.1	glycosyltransferase	-
HUZ56_RS05720 (HUZ56_05710)	1161609..1162064	+	456	WP_225373941.1	hypothetical protein	-
HUZ56_RS05725 (HUZ56_05715)	1162144..1162518	-	375	WP_004114636.1	TA system toxin CbtA family protein	Toxin
HUZ56_RS05730 (HUZ56_05720)	1162568..1162927	-	360	WP_004114633.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HUZ56_RS05735 (HUZ56_05725)	1162950..1163171	-	222	WP_004114632.1	DUF987 domain-containing protein	-
HUZ56_RS05740 (HUZ56_05730)	1163185..1163667	-	483	WP_004114630.1	DNA repair protein RadC	-
HUZ56_RS05745 (HUZ56_05735)	1163908..1164387	-	480	WP_004114626.1	antirestriction protein	-
HUZ56_RS05750 (HUZ56_05740)	1164467..1165288	-	822	WP_004114624.1	DUF932 domain-containing protein	-
HUZ56_RS05755 (HUZ56_05745)	1165399..1165611	-	213	WP_004114623.1	hypothetical protein	-
HUZ56_RS05760 (HUZ56_05750)	1165696..1166055	-	360	WP_004114622.1	hypothetical protein	-
HUZ56_RS05765 (HUZ56_05755)	1166110..1166574	-	465	WP_004114621.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1154362..1190474	36112

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (9-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13888.90 Da
• Isoelectric Point: 9.4643

>T160861 WP_004114636.1 NZ_CP054997:c1162518-1162144 [Klebsiella pneumoniae]
MQIQSLPPQRVASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSLDMLRARKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 375 bp

>T160861 NZ_CP070955:c16125-15709 [Escherichia fergusonii]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13425.66 Da
• Isoelectric Point: 8.1475

>AT160861 WP_004114633.1 NZ_CP054997:c1162927-1162568 [Klebsiella pneumoniae]
MKKATRIINHNIAEPWWGLRRNITPCLGARLVQEGNRLHYLADRASIAGTFNDTDLRHLDQAFPVLMKQMELMLASSELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTYAITA

Nucleotide

• Length: 360 bp

>AT160861 NZ_CP070955:c16352-16122 [Escherichia fergusonii]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA