Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789743..790400 Replicon chromosome
Accession NZ_CP054997
Organism Klebsiella pneumoniae strain STIN_84

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ56_RS03905 Protein ID WP_002916310.1
Coordinates 789990..790400 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ56_RS03900 Protein ID WP_002916312.1
Coordinates 789743..790009 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ56_RS03875 (HUZ56_03870) 784899..786332 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HUZ56_RS03880 (HUZ56_03875) 786451..787179 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ56_RS03885 (HUZ56_03880) 787229..787540 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ56_RS03890 (HUZ56_03885) 787704..788363 + 660 WP_002916317.1 hemolysin III family protein -
HUZ56_RS03895 (HUZ56_03890) 788514..789497 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HUZ56_RS03900 (HUZ56_03895) 789743..790009 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ56_RS03905 (HUZ56_03900) 789990..790400 + 411 WP_002916310.1 protein YgfX Toxin
HUZ56_RS03910 (HUZ56_03905) 790407..790928 - 522 WP_004144730.1 flavodoxin FldB -
HUZ56_RS03915 (HUZ56_03910) 791029..791925 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ56_RS03920 (HUZ56_03915) 791948..792661 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ56_RS03925 (HUZ56_03920) 792667..794400 + 1734 WP_211603646.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T160860 WP_002916310.1 NZ_CP054997:789990-790400 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T160860 NZ_CP070954:c3996237-3995947 [Escherichia fergusonii]
ATGAACTATGAACTGGCTTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGAAAGTCCGGGAACAATTTAA
AAAAAAGCTTGGGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTACGGGATTTGCCGGACTGCTACAAAATTA
AGCTTCGCACACTGGGATATCGCCGGGTCTATCAGGTCAATGATAAAGAGTTGATCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT160860 WP_002916312.1 NZ_CP054997:789743-790009 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT160860 NZ_CP070954:c3996469-3996227 [Escherichia fergusonii]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAGGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References