Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 1836514..1837345 | Replicon | chromosome |
Accession | NZ_CP054992 | ||
Organism | Shigella flexneri strain STIN_87 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | - |
Locus tag | HUZ57_RS08825 | Protein ID | WP_039268420.1 |
Coordinates | 1836514..1836888 (-) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | F4THW5 |
Locus tag | HUZ57_RS08830 | Protein ID | WP_001313071.1 |
Coordinates | 1836977..1837345 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUZ57_RS08785 (1831910) | 1831910..1833076 | + | 1167 | WP_001310935.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
HUZ57_RS08790 (1833195) | 1833195..1833668 | + | 474 | WP_001105393.1 | DNA gyrase inhibitor SbmC | - |
HUZ57_RS08795 (1833866) | 1833866..1834924 | + | 1059 | WP_001200905.1 | FUSC family protein | - |
HUZ57_RS08800 (1835096) | 1835096..1835425 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
HUZ57_RS08805 (1835526) | 1835526..1835849 | - | 324 | WP_223216378.1 | EutP/PduV family microcompartment system protein | - |
HUZ57_RS08810 (1835828) | 1835828..1835908 | + | 81 | WP_023441679.1 | hypothetical protein | - |
HUZ57_RS08815 (1836197) | 1836197..1836277 | - | 81 | Protein_1730 | hypothetical protein | - |
HUZ57_RS08820 (1836323) | 1836323..1836517 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
HUZ57_RS08825 (1836514) | 1836514..1836888 | - | 375 | WP_039268420.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
HUZ57_RS08830 (1836977) | 1836977..1837345 | - | 369 | WP_001313071.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HUZ57_RS08835 (1837425) | 1837425..1837646 | - | 222 | WP_000692301.1 | DUF987 domain-containing protein | - |
HUZ57_RS08840 (1837709) | 1837709..1838185 | - | 477 | WP_001186726.1 | RadC family protein | - |
HUZ57_RS08845 (1838201) | 1838201..1838680 | - | 480 | WP_000860076.1 | antirestriction protein | - |
HUZ57_RS08850 (1838762) | 1838762..1839583 | - | 822 | WP_001234530.1 | DUF932 domain-containing protein | - |
HUZ57_RS08855 (1839804) | 1839804..1840136 | - | 333 | Protein_1738 | hypothetical protein | - |
HUZ57_RS08865 (1840982) | 1840982..1841170 | + | 189 | Protein_1740 | IS4 family transposase | - |
HUZ57_RS08870 (1841149) | 1841149..1841322 | + | 174 | Protein_1741 | cobalamin biosynthesis protein | - |
HUZ57_RS08875 (1841474) | 1841474..1842019 | + | 546 | WP_000973176.1 | bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1792325..1853593 | 61268 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14000.00 Da Isoelectric Point: 7.1333
>T160840 WP_039268420.1 NZ_CP054992:c1836888-1836514 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T160840 NZ_CP070951:c4206756-4206649 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13498.23 Da Isoelectric Point: 5.8696
>AT160840 WP_001313071.1 NZ_CP054992:c1837345-1836977 [Shigella flexneri]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT160840 NZ_CP070951:4206804-4206870 [Escherichia fergusonii]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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