Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 695409..696243 | Replicon | chromosome |
Accession | NZ_CP054992 | ||
Organism | Shigella flexneri strain STIN_87 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | - |
Locus tag | HUZ57_RS03350 | Protein ID | WP_000854819.1 |
Coordinates | 695866..696243 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | - |
Locus tag | HUZ57_RS03345 | Protein ID | WP_112868929.1 |
Coordinates | 695409..695777 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUZ57_RS03320 (692833) | 692833..693066 | + | 234 | WP_123059057.1 | DUF905 family protein | - |
HUZ57_RS03325 (693157) | 693157..693975 | + | 819 | WP_112868927.1 | DUF932 domain-containing protein | - |
HUZ57_RS03330 (694067) | 694067..694552 | + | 486 | WP_112868928.1 | antirestriction protein | - |
HUZ57_RS03335 (694568) | 694568..695044 | + | 477 | WP_143364304.1 | RadC family protein | - |
HUZ57_RS03340 (695113) | 695113..695334 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
HUZ57_RS03345 (695409) | 695409..695777 | + | 369 | WP_112868929.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HUZ57_RS03350 (695866) | 695866..696243 | + | 378 | WP_000854819.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
HUZ57_RS03355 (696240) | 696240..696728 | + | 489 | WP_032215286.1 | DUF5983 family protein | - |
HUZ57_RS03360 (696748) | 696748..696945 | + | 198 | WP_000772024.1 | DUF957 domain-containing protein | - |
HUZ57_RS03365 (697042) | 697042..697887 | + | 846 | WP_089653271.1 | DUF4942 domain-containing protein | - |
HUZ57_RS03375 (698187) | 698187..698693 | + | 507 | WP_000228937.1 | G/U mismatch-specific DNA glycosylase | - |
HUZ57_RS03380 (698772) | 698772..700613 | - | 1842 | WP_000437375.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | rfaE | 663398..748609 | 85211 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14160.18 Da Isoelectric Point: 7.8523
>T160835 WP_000854819.1 NZ_CP054992:695866-696243 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
Download Length: 378 bp
>T160835 NZ_CP070951:c2171023-2170745 [Escherichia fergusonii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATCTCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATCTCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13730.41 Da Isoelectric Point: 5.0472
>AT160835 WP_112868929.1 NZ_CP054992:695409-695777 [Shigella flexneri]
VSDTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT160835 NZ_CP070951:c2170745-2170461 [Escherichia fergusonii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCCGCGTTGACGCCAGAAATGGCGA
TTAAACTTTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTACAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCCGCGTTGACGCCAGAAATGGCGA
TTAAACTTTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTACAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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