Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 695409..696243 Replicon chromosome
Accession NZ_CP054992
Organism Shigella flexneri strain STIN_87

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HUZ57_RS03350 Protein ID WP_000854819.1
Coordinates 695866..696243 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HUZ57_RS03345 Protein ID WP_112868929.1
Coordinates 695409..695777 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ57_RS03320 (692833) 692833..693066 + 234 WP_123059057.1 DUF905 family protein -
HUZ57_RS03325 (693157) 693157..693975 + 819 WP_112868927.1 DUF932 domain-containing protein -
HUZ57_RS03330 (694067) 694067..694552 + 486 WP_112868928.1 antirestriction protein -
HUZ57_RS03335 (694568) 694568..695044 + 477 WP_143364304.1 RadC family protein -
HUZ57_RS03340 (695113) 695113..695334 + 222 WP_001220314.1 DUF987 domain-containing protein -
HUZ57_RS03345 (695409) 695409..695777 + 369 WP_112868929.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ57_RS03350 (695866) 695866..696243 + 378 WP_000854819.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HUZ57_RS03355 (696240) 696240..696728 + 489 WP_032215286.1 DUF5983 family protein -
HUZ57_RS03360 (696748) 696748..696945 + 198 WP_000772024.1 DUF957 domain-containing protein -
HUZ57_RS03365 (697042) 697042..697887 + 846 WP_089653271.1 DUF4942 domain-containing protein -
HUZ57_RS03375 (698187) 698187..698693 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
HUZ57_RS03380 (698772) 698772..700613 - 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 663398..748609 85211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14160.18 Da        Isoelectric Point: 7.8523

>T160835 WP_000854819.1 NZ_CP054992:695866-696243 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T160835 NZ_CP070951:c2171023-2170745 [Escherichia fergusonii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATCTCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13730.41 Da        Isoelectric Point: 5.0472

>AT160835 WP_112868929.1 NZ_CP054992:695409-695777 [Shigella flexneri]
VSDTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT160835 NZ_CP070951:c2170745-2170461 [Escherichia fergusonii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAGCTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCCGCGTTGACGCCAGAAATGGCGA
TTAAACTTTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTACAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTAGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References