Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 13722..14365 | Replicon | plasmid unnamed4 |
| Accession | NZ_CP054988 | ||
| Organism | Klebsiella pneumoniae strain STIN_90 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q84A06 |
| Locus tag | HUZ59_RS28390 | Protein ID | WP_000754566.1 |
| Coordinates | 13722..14138 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q84A07 |
| Locus tag | HUZ59_RS28395 | Protein ID | WP_001261276.1 |
| Coordinates | 14135..14365 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ59_RS28360 (HUZ59_28305) | 9501..9737 | - | 237 | WP_223417154.1 | transposase | - |
| HUZ59_RS28365 (HUZ59_28310) | 9832..10044 | - | 213 | Protein_10 | 3'-5' exonuclease | - |
| HUZ59_RS28370 (HUZ59_28315) | 10090..10368 | - | 279 | WP_001384452.1 | type II toxin-antitoxin system toxin YacB | - |
| HUZ59_RS28375 (HUZ59_28320) | 10368..10637 | - | 270 | WP_021546940.1 | type II toxin-antitoxin system antitoxin YacA | - |
| HUZ59_RS28380 (HUZ59_28325) | 11304..12380 | - | 1077 | WP_000227969.1 | IS110 family transposase | - |
| HUZ59_RS28385 (HUZ59_28330) | 12662..13518 | - | 857 | Protein_14 | IS3-like element ISEc15 family transposase | - |
| HUZ59_RS28390 (HUZ59_28335) | 13722..14138 | - | 417 | WP_000754566.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| HUZ59_RS28395 (HUZ59_28340) | 14135..14365 | - | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| HUZ59_RS28400 (HUZ59_28345) | 14939..15289 | + | 351 | WP_000493378.1 | hypothetical protein | - |
| HUZ59_RS28405 (HUZ59_28350) | 15340..16083 | + | 744 | WP_000129823.1 | hypothetical protein | - |
| HUZ59_RS28410 (HUZ59_28355) | 16080..16856 | + | 777 | WP_000015958.1 | site-specific integrase | - |
| HUZ59_RS28415 (HUZ59_28360) | 16914..17171 | - | 258 | WP_000764642.1 | hypothetical protein | - |
| HUZ59_RS28420 (HUZ59_28365) | 17300..17404 | - | 105 | WP_032409716.1 | hypothetical protein | - |
| HUZ59_RS28425 (HUZ59_28370) | 17934..18800 | + | 867 | WP_004118283.1 | replication initiation protein | - |
| HUZ59_RS28430 (HUZ59_28375) | 18977..19246 | - | 270 | WP_000339857.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | cmlA1 / aadA2 / dfrA12 / tet(A) / floR / qnrS1 / aph(3')-Ia / mef(B) / sul3 | - | 1..68256 | 68256 | |
| - | inside | IScluster/Tn | cmlA1 / aadA2 / dfrA12 | - | 614..13518 | 12904 | |
| - | inside | Integron | - | - | 3..68255 | 68252 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15006.52 Da Isoelectric Point: 9.2957
>T160832 WP_000754566.1 NZ_CP054988:c14138-13722 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T160832 NZ_CP070951:927553-927888 [Escherichia fergusonii]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGTGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGTGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT160832 WP_001261276.1 NZ_CP054988:c14365-14135 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT160832 NZ_CP070951:927305-927553 [Escherichia fergusonii]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGGTGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGGTGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K1G3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K023 |