Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4751845..4752361 Replicon chromosome
Accession NZ_CP054984
Organism Klebsiella pneumoniae strain STIN_90

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag HUZ59_RS22995 Protein ID WP_009486548.1
Coordinates 4751845..4752129 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ59_RS23000 Protein ID WP_002886901.1
Coordinates 4752119..4752361 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ59_RS22970 (4747262) 4747262..4747525 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HUZ59_RS22975 (4747655) 4747655..4747828 + 174 WP_002886906.1 hypothetical protein -
HUZ59_RS22980 (4747831) 4747831..4748574 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ59_RS22985 (4748931) 4748931..4751069 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ59_RS22990 (4751377) 4751377..4751841 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ59_RS22995 (4751845) 4751845..4752129 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ59_RS23000 (4752119) 4752119..4752361 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ59_RS23005 (4752439) 4752439..4754349 - 1911 WP_009486549.1 PRD domain-containing protein -
HUZ59_RS23010 (4754372) 4754372..4755526 - 1155 WP_020316350.1 lactonase family protein -
HUZ59_RS23015 (4755593) 4755593..4756333 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T160825 WP_009486548.1 NZ_CP054984:c4752129-4751845 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T160825 NZ_CP070930:3988006-3988347 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGTTGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCCGCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT160825 WP_002886901.1 NZ_CP054984:c4752361-4752119 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT160825 NZ_CP070930:c3988011-3987935 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References