Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4013900..4014519 Replicon chromosome
Accession NZ_CP054984
Organism Klebsiella pneumoniae strain STIN_90

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUZ59_RS19420 Protein ID WP_002892050.1
Coordinates 4014301..4014519 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HUZ59_RS19415 Protein ID WP_080789174.1
Coordinates 4013900..4014274 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ59_RS19405 (4009052) 4009052..4010245 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUZ59_RS19410 (4010268) 4010268..4013414 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HUZ59_RS19415 (4013900) 4013900..4014274 + 375 WP_080789174.1 Hha toxicity modulator TomB Antitoxin
HUZ59_RS19420 (4014301) 4014301..4014519 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HUZ59_RS19425 (4014678) 4014678..4015244 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUZ59_RS19430 (4015216) 4015216..4015356 - 141 WP_004147370.1 hypothetical protein -
HUZ59_RS19435 (4015377) 4015377..4015847 + 471 WP_002892026.1 YlaC family protein -
HUZ59_RS19440 (4015822) 4015822..4017272 - 1451 Protein_3820 PLP-dependent aminotransferase family protein -
HUZ59_RS19445 (4017373) 4017373..4018071 + 699 WP_002892021.1 GNAT family protein -
HUZ59_RS19450 (4018068) 4018068..4018208 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUZ59_RS19455 (4018208) 4018208..4018471 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T160823 WP_002892050.1 NZ_CP054984:4014301-4014519 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T160823 NZ_CP070930:c3625461-3625063 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTTTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14295.99 Da        Isoelectric Point: 5.1444

>AT160823 WP_080789174.1 NZ_CP054984:4013900-4014274 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAGDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT160823 NZ_CP070930:c3625757-3625464 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References