Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807848..808505 Replicon chromosome
Accession NZ_CP054984
Organism Klebsiella pneumoniae strain STIN_90

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ59_RS03970 Protein ID WP_002916310.1
Coordinates 808095..808505 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ59_RS03965 Protein ID WP_002916312.1
Coordinates 807848..808114 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ59_RS03940 (803004) 803004..804437 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HUZ59_RS03945 (804556) 804556..805284 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
HUZ59_RS03950 (805334) 805334..805645 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ59_RS03955 (805809) 805809..806468 + 660 WP_002916317.1 hemolysin III family protein -
HUZ59_RS03960 (806619) 806619..807602 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HUZ59_RS03965 (807848) 807848..808114 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ59_RS03970 (808095) 808095..808505 + 411 WP_002916310.1 protein YgfX Toxin
HUZ59_RS03975 (808512) 808512..809033 - 522 WP_002916308.1 flavodoxin FldB -
HUZ59_RS03980 (809134) 809134..810030 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ59_RS03985 (810053) 810053..810766 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ59_RS03990 (810772) 810772..812505 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T160813 WP_002916310.1 NZ_CP054984:808095-808505 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T160813 NZ_CP070930:995892-996227 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT160813 WP_002916312.1 NZ_CP054984:807848-808114 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT160813 NZ_CP070930:995644-995892 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCAGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References