Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2330251..2330777 | Replicon | chromosome |
| Accession | NZ_CP054977 | ||
| Organism | Shigella flexneri strain STIN_92 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HUZ60_RS11340 | Protein ID | WP_000323025.1 |
| Coordinates | 2330490..2330777 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HUZ60_RS11335 | Protein ID | WP_000534858.1 |
| Coordinates | 2330251..2330490 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ60_RS11305 (2325979) | 2325979..2326209 | - | 231 | Protein_2220 | IS66 family insertion sequence element accessory protein TnpB | - |
| HUZ60_RS11310 (2326215) | 2326215..2326337 | - | 123 | Protein_2221 | transposase | - |
| HUZ60_RS11315 (2326580) | 2326580..2327001 | + | 422 | Protein_2222 | hypothetical protein | - |
| HUZ60_RS11320 (2327636) | 2327636..2328949 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| HUZ60_RS11325 (2329386) | 2329386..2329718 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| HUZ60_RS11330 (2329921) | 2329921..2330226 | - | 306 | WP_001326990.1 | protein YdfV | - |
| HUZ60_RS11335 (2330251) | 2330251..2330490 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HUZ60_RS11340 (2330490) | 2330490..2330777 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HUZ60_RS11345 (2330849) | 2330849..2331004 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HUZ60_RS11350 (2331221) | 2331221..2331472 | + | 252 | WP_000980994.1 | protein Rem | - |
| HUZ60_RS11355 (2331539) | 2331539..2331817 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| HUZ60_RS11360 (2331819) | 2331819..2332868 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| HUZ60_RS11365 (2332882) | 2332882..2333634 | + | 753 | WP_001047135.1 | antitermination protein | - |
| HUZ60_RS11370 (2333912) | 2333912..2334001 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| HUZ60_RS11375 (2334056) | 2334056..2334268 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HUZ60_RS11380 (2334569) | 2334569..2334784 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| HUZ60_RS11385 (2335148) | 2335148..2335318 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2314304..2349392 | 35088 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T160788 WP_000323025.1 NZ_CP054977:2330490-2330777 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T160788 NZ_CP070920:1000951-1001286 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT160788 WP_000534858.1 NZ_CP054977:2330251-2330490 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT160788 NZ_CP070920:1000703-1000951 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|