Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4618487..4619167 Replicon chromosome
Accession NZ_CP054972
Organism Klebsiella pneumoniae strain STIN_93

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HUZ61_RS22515 Protein ID WP_032439574.1
Coordinates 4618487..4618807 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HUZ61_RS22520 Protein ID WP_032439585.1
Coordinates 4618844..4619167 (-) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ61_RS22490 (4613692) 4613692..4614576 + 885 WP_085838648.1 RES domain-containing protein -
HUZ61_RS22495 (4614775) 4614775..4614963 - 189 Protein_4413 transposase -
HUZ61_RS22500 (4614980) 4614980..4616091 - 1112 Protein_4414 IS3 family transposase -
HUZ61_RS22505 (4616459) 4616459..4617466 - 1008 WP_032439165.1 restriction endonuclease -
HUZ61_RS22510 (4617543) 4617543..4618373 - 831 WP_032439575.1 DUF4942 domain-containing protein -
HUZ61_RS22515 (4618487) 4618487..4618807 - 321 WP_032439574.1 TA system toxin CbtA family protein Toxin
HUZ61_RS22520 (4618844) 4618844..4619167 - 324 WP_032439585.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ61_RS22525 (4619180) 4619180..4619650 - 471 WP_239593394.1 DNA repair protein RadC -
HUZ61_RS22530 (4619721) 4619721..4620542 - 822 WP_032439572.1 DUF932 domain-containing protein -
HUZ61_RS22535 (4620641) 4620641..4620853 - 213 WP_032439571.1 hypothetical protein -
HUZ61_RS22540 (4620927) 4620927..4621283 - 357 WP_223366209.1 hypothetical protein -
HUZ61_RS22545 (4621356) 4621356..4621820 - 465 WP_032439584.1 hypothetical protein -
HUZ61_RS22550 (4622692) 4622692..4624146 + 1455 WP_239593396.1 YfjI family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4605869..4636331 30462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-105)

Antitoxin

(7-106)


Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12030.64 Da        Isoelectric Point: 6.6410

>T160766 WP_032439574.1 NZ_CP054972:c4618807-4618487 [Klebsiella pneumoniae]
MHISTVPAKVSVSSRLSPVQVWQQLLTYLLNHHYGLTLNDTPFHDDTAIQEHIEAGIALADAVNFLVERYELVRTDRKGF
TWQDQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T160766 NZ_CP070914:726640-726936 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12061.75 Da        Isoelectric Point: 7.2415

>AT160766 WP_032439585.1 NZ_CP054972:c4619167-4618844 [Klebsiella pneumoniae]
MPFTLPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGEITPKQLQKLDQTFPLFISQLEAMLRSGELNSQQQHQVT
IQRASLTCIADTRGSCGYVYISIYPTP

Download         Length: 324 bp

>AT160766 NZ_CP070914:726938-727333 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References