Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 4618487..4619167 | Replicon | chromosome |
Accession | NZ_CP054972 | ||
Organism | Klebsiella pneumoniae strain STIN_93 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | - |
Locus tag | HUZ61_RS22515 | Protein ID | WP_032439574.1 |
Coordinates | 4618487..4618807 (-) | Length | 107 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | - |
Locus tag | HUZ61_RS22520 | Protein ID | WP_032439585.1 |
Coordinates | 4618844..4619167 (-) | Length | 108 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUZ61_RS22490 (4613692) | 4613692..4614576 | + | 885 | WP_085838648.1 | RES domain-containing protein | - |
HUZ61_RS22495 (4614775) | 4614775..4614963 | - | 189 | Protein_4413 | transposase | - |
HUZ61_RS22500 (4614980) | 4614980..4616091 | - | 1112 | Protein_4414 | IS3 family transposase | - |
HUZ61_RS22505 (4616459) | 4616459..4617466 | - | 1008 | WP_032439165.1 | restriction endonuclease | - |
HUZ61_RS22510 (4617543) | 4617543..4618373 | - | 831 | WP_032439575.1 | DUF4942 domain-containing protein | - |
HUZ61_RS22515 (4618487) | 4618487..4618807 | - | 321 | WP_032439574.1 | TA system toxin CbtA family protein | Toxin |
HUZ61_RS22520 (4618844) | 4618844..4619167 | - | 324 | WP_032439585.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HUZ61_RS22525 (4619180) | 4619180..4619650 | - | 471 | WP_239593394.1 | DNA repair protein RadC | - |
HUZ61_RS22530 (4619721) | 4619721..4620542 | - | 822 | WP_032439572.1 | DUF932 domain-containing protein | - |
HUZ61_RS22535 (4620641) | 4620641..4620853 | - | 213 | WP_032439571.1 | hypothetical protein | - |
HUZ61_RS22540 (4620927) | 4620927..4621283 | - | 357 | WP_223366209.1 | hypothetical protein | - |
HUZ61_RS22545 (4621356) | 4621356..4621820 | - | 465 | WP_032439584.1 | hypothetical protein | - |
HUZ61_RS22550 (4622692) | 4622692..4624146 | + | 1455 | WP_239593396.1 | YfjI family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4605869..4636331 | 30462 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12030.64 Da Isoelectric Point: 6.6410
>T160766 WP_032439574.1 NZ_CP054972:c4618807-4618487 [Klebsiella pneumoniae]
MHISTVPAKVSVSSRLSPVQVWQQLLTYLLNHHYGLTLNDTPFHDDTAIQEHIEAGIALADAVNFLVERYELVRTDRKGF
TWQDQTPFLTATDILRARRATGLINT
MHISTVPAKVSVSSRLSPVQVWQQLLTYLLNHHYGLTLNDTPFHDDTAIQEHIEAGIALADAVNFLVERYELVRTDRKGF
TWQDQTPFLTATDILRARRATGLINT
Download Length: 321 bp
>T160766 NZ_CP070914:726640-726936 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12061.75 Da Isoelectric Point: 7.2415
>AT160766 WP_032439585.1 NZ_CP054972:c4619167-4618844 [Klebsiella pneumoniae]
MPFTLPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGEITPKQLQKLDQTFPLFISQLEAMLRSGELNSQQQHQVT
IQRASLTCIADTRGSCGYVYISIYPTP
MPFTLPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGEITPKQLQKLDQTFPLFISQLEAMLRSGELNSQQQHQVT
IQRASLTCIADTRGSCGYVYISIYPTP
Download Length: 324 bp
>AT160766 NZ_CP070914:726938-727333 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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