160746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4651207..4651723 Replicon chromosome
Accession NZ_CP054967
Organism Klebsiella pneumoniae strain STIN_94

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag HUZ62_RS22610 Protein ID WP_009486548.1
Coordinates 4651207..4651491 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ62_RS22615 Protein ID WP_002886901.1
Coordinates 4651481..4651723 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ62_RS22585 (4646624) 4646624..4646887 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HUZ62_RS22590 (4647017) 4647017..4647190 + 174 WP_032433782.1 hypothetical protein -
HUZ62_RS22595 (4647193) 4647193..4647936 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ62_RS22600 (4648293) 4648293..4650431 + 2139 WP_032418145.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ62_RS22605 (4650739) 4650739..4651203 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ62_RS22610 (4651207) 4651207..4651491 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ62_RS22615 (4651481) 4651481..4651723 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ62_RS22620 (4651801) 4651801..4653711 - 1911 WP_009486549.1 PRD domain-containing protein -
HUZ62_RS22625 (4653734) 4653734..4654888 - 1155 WP_002886900.1 lactonase family protein -
HUZ62_RS22630 (4654955) 4654955..4655695 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T160746 WP_009486548.1 NZ_CP054967:c4651491-4651207 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T160746 NZ_CP070906:1849382-1849633 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT160746 WP_002886901.1 NZ_CP054967:c4651723-4651481 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT160746 NZ_CP070906:1849630-1849884 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References