Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 1417092..1417735 | Replicon | chromosome |
| Accession | NZ_CP054967 | ||
| Organism | Klebsiella pneumoniae strain STIN_94 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A4S8C081 |
| Locus tag | HUZ62_RS06935 | Protein ID | WP_032433387.1 |
| Coordinates | 1417319..1417735 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q84A07 |
| Locus tag | HUZ62_RS06930 | Protein ID | WP_001261276.1 |
| Coordinates | 1417092..1417322 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ62_RS06915 (1412114) | 1412114..1413201 | + | 1088 | Protein_1350 | transcriptional repressor PifC | - |
| HUZ62_RS06920 (1413204) | 1413204..1415444 | + | 2241 | WP_045326788.1 | P-loop NTPase fold protein | - |
| HUZ62_RS06925 (1415972) | 1415972..1416787 | - | 816 | WP_032433388.1 | hypothetical protein | - |
| HUZ62_RS06930 (1417092) | 1417092..1417322 | + | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| HUZ62_RS06935 (1417319) | 1417319..1417735 | + | 417 | WP_032433387.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| HUZ62_RS06940 (1417891) | 1417891..1418871 | + | 981 | WP_032433385.1 | hypothetical protein | - |
| HUZ62_RS06945 (1419066) | 1419066..1420637 | - | 1572 | WP_032433383.1 | AAA family ATPase | - |
| HUZ62_RS06950 (1420956) | 1420956..1421204 | + | 249 | WP_032433382.1 | hypothetical protein | - |
| HUZ62_RS06955 (1421263) | 1421263..1421781 | + | 519 | WP_045326794.1 | hypothetical protein | - |
| HUZ62_RS06960 (1421812) | 1421812..1422303 | + | 492 | WP_032433378.1 | hypothetical protein | - |
| HUZ62_RS06965 (1422363) | 1422363..1422566 | + | 204 | WP_032433376.1 | HHA domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1401728..1447745 | 46017 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14974.43 Da Isoelectric Point: 7.8921
>T160733 WP_032433387.1 NZ_CP054967:1417319-1417735 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI
Download Length: 417 bp
>T160733 NZ_CP070902:2694866-2694973 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGTCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGTCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT160733 WP_001261276.1 NZ_CP054967:1417092-1417322 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT160733 NZ_CP070902:c2694818-2694752 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4S8C081 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K023 |