Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798946..799603 Replicon chromosome
Accession NZ_CP054967
Organism Klebsiella pneumoniae strain STIN_94

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ62_RS03955 Protein ID WP_002916310.1
Coordinates 799193..799603 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ62_RS03950 Protein ID WP_002916312.1
Coordinates 798946..799212 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ62_RS03925 (794102) 794102..795535 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HUZ62_RS03930 (795654) 795654..796382 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ62_RS03935 (796432) 796432..796743 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ62_RS03940 (796907) 796907..797566 + 660 WP_002916317.1 hemolysin III family protein -
HUZ62_RS03945 (797717) 797717..798700 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HUZ62_RS03950 (798946) 798946..799212 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ62_RS03955 (799193) 799193..799603 + 411 WP_002916310.1 protein YgfX Toxin
HUZ62_RS03960 (799610) 799610..800131 - 522 WP_004144730.1 flavodoxin FldB -
HUZ62_RS03965 (800232) 800232..801128 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ62_RS03970 (801151) 801151..801864 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ62_RS03975 (801870) 801870..803603 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T160732 WP_002916310.1 NZ_CP054967:799193-799603 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T160732 NZ_CP070902:c2488354-2488178 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT160732 WP_002916312.1 NZ_CP054967:798946-799212 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT160732 NZ_CP070902:c2488132-2487716 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References