Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2985421..2986216 Replicon chromosome
Accession NZ_CP054965
Organism Escherichia coli strain STIN_95

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag HUZ63_RS14400 Protein ID WP_001094434.1
Coordinates 2985421..2985795 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HUZ63_RS14405 Protein ID WP_001285482.1
Coordinates 2985842..2986216 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ63_RS14365 (2981010) 2981010..2981564 - 555 WP_001001913.1 molecular chaperone YcdY -
HUZ63_RS14370 (2981588) 2981588..2982325 - 738 WP_000283656.1 zinc-binding phosphatase -
HUZ63_RS14375 (2982380) 2982380..2983318 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
HUZ63_RS14385 (2983789) 2983789..2984631 - 843 WP_001280460.1 DUF4942 domain-containing protein -
HUZ63_RS14390 (2984724) 2984724..2984921 - 198 WP_000839257.1 DUF957 domain-containing protein -
HUZ63_RS14395 (2984933) 2984933..2985424 - 492 WP_000976859.1 DUF5983 family protein -
HUZ63_RS14400 (2985421) 2985421..2985795 - 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
HUZ63_RS14405 (2985842) 2985842..2986216 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ63_RS14410 (2986266) 2986266..2986910 - 645 WP_000086762.1 hypothetical protein -
HUZ63_RS14415 (2986929) 2986929..2987150 - 222 WP_000692315.1 DUF987 domain-containing protein -
HUZ63_RS14420 (2987213) 2987213..2987689 - 477 WP_001313574.1 RadC family protein -
HUZ63_RS14425 (2987705) 2987705..2988178 - 474 WP_001313575.1 antirestriction protein -
HUZ63_RS14430 (2988515) 2988515..2989336 - 822 WP_001234582.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T160716 WP_001094434.1 NZ_CP054965:c2985795-2985421 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T160716 NZ_CP070898:c5189613-5189230 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT160716 WP_001285482.1 NZ_CP054965:c2986216-2985842 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT160716 NZ_CP070898:c5189855-5189613 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1RDD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References