Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1925078..1925909 | Replicon | chromosome |
| Accession | NZ_CP054965 | ||
| Organism | Escherichia coli strain STIN_95 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | HUZ63_RS09070 | Protein ID | WP_071448168.1 |
| Coordinates | 1925078..1925452 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1PWQ3 |
| Locus tag | HUZ63_RS09075 | Protein ID | WP_001285586.1 |
| Coordinates | 1925541..1925909 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ63_RS09030 (1920474) | 1920474..1921640 | + | 1167 | WP_001519880.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| HUZ63_RS09035 (1921759) | 1921759..1922232 | + | 474 | WP_001105376.1 | DNA gyrase inhibitor SbmC | - |
| HUZ63_RS09040 (1922430) | 1922430..1923488 | + | 1059 | WP_001200890.1 | FUSC family protein | - |
| HUZ63_RS09045 (1923660) | 1923660..1923989 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| HUZ63_RS09050 (1924090) | 1924090..1924413 | - | 324 | WP_223216378.1 | EutP/PduV family microcompartment system protein | - |
| HUZ63_RS09055 (1924392) | 1924392..1924472 | + | 81 | WP_023441679.1 | hypothetical protein | - |
| HUZ63_RS09060 (1924761) | 1924761..1924841 | - | 81 | Protein_1778 | hypothetical protein | - |
| HUZ63_RS09065 (1924887) | 1924887..1925081 | - | 195 | WP_000988601.1 | DUF5983 family protein | - |
| HUZ63_RS09070 (1925078) | 1925078..1925452 | - | 375 | WP_071448168.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| HUZ63_RS09075 (1925541) | 1925541..1925909 | - | 369 | WP_001285586.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| HUZ63_RS09080 (1925983) | 1925983..1926204 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| HUZ63_RS09085 (1926273) | 1926273..1926749 | - | 477 | WP_001351157.1 | RadC family protein | - |
| HUZ63_RS09090 (1926765) | 1926765..1927250 | - | 486 | WP_239634743.1 | antirestriction protein | - |
| HUZ63_RS09095 (1927341) | 1927341..1928162 | - | 822 | WP_001234569.1 | DUF932 domain-containing protein | - |
| HUZ63_RS09100 (1928383) | 1928383..1928793 | - | 411 | WP_000846704.1 | hypothetical protein | - |
| HUZ63_RS09105 (1928809) | 1928809..1929486 | - | 678 | WP_001362823.1 | hypothetical protein | - |
| HUZ63_RS09110 (1929622) | 1929622..1930692 | - | 1071 | WP_000102631.1 | patatin-like phospholipase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13879.89 Da Isoelectric Point: 7.2424
>T160705 WP_071448168.1 NZ_CP054965:c1925452-1925078 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T160705 NZ_CP070896:3597923-3598186 [Hungatella xylanolytica]
ATGAATAAAGTGTTTACAAAGAACGGATGGGATGATTATATTTATTGGCAGACGGAAGATAGAAAAATATTAAGAAAAAT
AAATCATTTGATTGAAGATATTGCTAGAAATGGGAATGAAGGAGTTGGAAAGCCAGAAGCTCTAAGCGGAAATCTAGCTG
GTTTTTGGAACAGAAGAATAAATGATAAAGATCGGTTGATATATAAAATTGATAATGAGAATATCTATATCTTGGCTTGT
AGATACCATTATGGCGATAAATGA
ATGAATAAAGTGTTTACAAAGAACGGATGGGATGATTATATTTATTGGCAGACGGAAGATAGAAAAATATTAAGAAAAAT
AAATCATTTGATTGAAGATATTGCTAGAAATGGGAATGAAGGAGTTGGAAAGCCAGAAGCTCTAAGCGGAAATCTAGCTG
GTTTTTGGAACAGAAGAATAAATGATAAAGATCGGTTGATATATAAAATTGATAATGAGAATATCTATATCTTGGCTTGT
AGATACCATTATGGCGATAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13563.41 Da Isoelectric Point: 5.0468
>AT160705 WP_001285586.1 NZ_CP054965:c1925909-1925541 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT160705 NZ_CP070896:3597664-3597930 [Hungatella xylanolytica]
ATGTTGGCAGTTAATTATACAACGTTAAGAGATAAAATGAAGACATATATGGATAAAATCACAGATGATTATGAGACATT
GATTGTTACAAGAAAGGATAACAAAAATGTTGTTATGCTGTCTGAAGAATCCTATAACAATATGATGGAAAATATATATG
TAATGGGAAATAAAAGTAATTATGATTGGTTAATTCAATCAAAGGCTCAGTTAGAAAATGGAATGGTATCCACTCATGAT
CTTCCTGAGGTAGAAGCTGATGAATAA
ATGTTGGCAGTTAATTATACAACGTTAAGAGATAAAATGAAGACATATATGGATAAAATCACAGATGATTATGAGACATT
GATTGTTACAAGAAAGGATAACAAAAATGTTGTTATGCTGTCTGAAGAATCCTATAACAATATGATGGAAAATATATATG
TAATGGGAAATAAAAGTAATTATGATTGGTTAATTCAATCAAAGGCTCAGTTAGAAAATGGAATGGTATCCACTCATGAT
CTTCCTGAGGTAGAAGCTGATGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|