160683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 110221..110780 Replicon plasmid pMS6192A-NDM
Accession NZ_CP054941
Organism Escherichia coli strain MS6192

Toxin (Protein)


Gene name relE Uniprot ID V0SVC8
Locus tag MS6192_RS24290 Protein ID WP_000421272.1
Coordinates 110505..110780 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SRR3
Locus tag MS6192_RS24285 Protein ID WP_001387467.1
Coordinates 110221..110505 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6192_RS24255 105684..106124 - 441 Protein_133 zinc-binding dehydrogenase -
MS6192_RS24260 106098..106292 + 195 WP_000796505.1 hypothetical protein -
MS6192_RS24265 106525..107415 + 891 WP_001077068.1 dihydrodipicolinate synthase family protein -
MS6192_RS24270 107440..107820 + 381 WP_000710783.1 Rid family detoxifying hydrolase -
MS6192_RS24275 107853..108818 + 966 WP_001022265.1 2-keto-3-deoxygluconate transporter -
MS6192_RS24280 108864..109616 - 753 WP_000562172.1 IclR family transcriptional regulator -
MS6192_RS24285 110221..110505 + 285 WP_001387467.1 ribbon-helix-helix domain-containing protein Antitoxin
MS6192_RS24290 110505..110780 + 276 WP_000421272.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MS6192_RS24295 110886..111179 + 294 WP_001105060.1 hypothetical protein -
MS6192_RS24300 111214..111342 - 129 Protein_142 IS481 family transposase -
MS6192_RS24305 111375..112544 - 1170 WP_001072355.1 hypothetical protein -
MS6192_RS24310 113037..113344 + 308 Protein_144 type II toxin-antitoxin system ParD family antitoxin -
MS6192_RS24315 113687..113869 + 183 WP_042065278.1 hypothetical protein -
MS6192_RS24320 113990..114730 + 741 WP_001066942.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / blaNDM-1 / sul1 / qacE / aadA2 / dfrA12 - 1..142890 142890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 10.0871

>T160683 WP_000421272.1 NZ_CP054941:110505-110780 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T160683 NZ_CP070873:3170074-3170177 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT160683 WP_001387467.1 NZ_CP054941:110221-110505 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR

Download         Length: 285 bp

>AT160683 NZ_CP070873:c3170215-3169948 [Escherichia fergusonii]
AAAGTCAGCGAAGGGAATTTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGT
TCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SVC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y880

References