Detailed information of TA system TA160641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3221103..3221628
• Replicon: chromosome
• Accession: NZ_CP054939
• Organism: Streptomyces sp. NA02536

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUT14_RS14355
• Protein ID: WP_121546319.1
• Coordinates: 3221362..3221628 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7H8J816
• Locus tag: HUT14_RS14350
• Protein ID: WP_040908670.1
• Coordinates: 3221103..3221369 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUT14_RS14320	3216566..3217327	+	762	WP_176117466.1	cobalt ECF transporter T component CbiQ	-
HUT14_RS14325	3217315..3218085	+	771	WP_176117467.1	energy-coupling factor ABC transporter ATP-binding protein	-
HUT14_RS14330	3218097..3218567	+	471	WP_004930328.1	MarR family transcriptional regulator	-
HUT14_RS14335	3218625..3219845	+	1221	WP_176117468.1	serine hydrolase	-
HUT14_RS14340	3219846..3220121	-	276	WP_121546318.1	DUF1876 domain-containing protein	-
HUT14_RS14345	3220203..3221048	-	846	WP_004930321.1	DMT family transporter	-
HUT14_RS14350	3221103..3221369	+	267	WP_040908670.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HUT14_RS14355	3221362..3221628	+	267	WP_121546319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUT14_RS14360	3221735..3223942	-	2208	WP_176117469.1	MMPL family transporter	-
HUT14_RS14365	3224043..3224642	-	600	WP_176117470.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-57)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10199.72 Da
• Isoelectric Point: 10.2960

>T160641 WP_121546319.1 NZ_CP054939:3221362-3221628 [Streptomyces sp. NA02536]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT

Nucleotide

• Length: 267 bp

>T160641 NZ_CP070598:c5270251-5269868 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10218.61 Da
• Isoelectric Point: 4.5329

>AT160641 WP_040908670.1 NZ_CP054939:3221103-3221369 [Streptomyces sp. NA02536]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE

Nucleotide

• Length: 267 bp

>AT160641 NZ_CP070598:c5270493-5270251 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A7H8J816