160640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2945060..2945625 Replicon chromosome
Accession NZ_CP054939
Organism Streptomyces sp. NA02536

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HUT14_RS13210 Protein ID WP_176117369.1
Coordinates 2945060..2945428 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HUT14_RS13215 Protein ID WP_121546169.1
Coordinates 2945428..2945625 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT14_RS13190 2940138..2941115 + 978 WP_176117367.1 glycine betaine ABC transporter substrate-binding protein -
HUT14_RS13195 2941112..2941903 - 792 WP_176117368.1 hypothetical protein -
HUT14_RS13200 2942210..2942851 - 642 WP_040907076.1 helix-turn-helix domain-containing protein -
HUT14_RS13205 2943136..2944935 - 1800 WP_004930870.1 DEAD/DEAH box helicase -
HUT14_RS13210 2945060..2945428 - 369 WP_176117369.1 Fic family protein Toxin
HUT14_RS13215 2945428..2945625 - 198 WP_121546169.1 hypothetical protein Antitoxin
HUT14_RS13220 2945658..2947118 - 1461 WP_176117370.1 MFS transporter -
HUT14_RS13230 2947415..2948674 + 1260 WP_176117371.1 hypothetical protein -
HUT14_RS13235 2948691..2949869 - 1179 WP_176117372.1 SUKH-4 family immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(14-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13719.64 Da        Isoelectric Point: 4.8336

>T160640 WP_176117369.1 NZ_CP054939:c2945428-2945060 [Streptomyces sp. NA02536]
MHYLTLPELLNLAKRLGEDVVRDYGLLDSALARPQSSVFGQDAYPDVWQKAAALMESLARNHALVDGNKRLAWYATWVFL
HMNGHPLDPDFDVDEAEQFVLDVCQGALDVPKIAAQLPRFAR

Download         Length: 369 bp

>T160640 NZ_CP070598:c4946733-4945816 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7349.21 Da        Isoelectric Point: 5.5900

>AT160640 WP_121546169.1 NZ_CP054939:c2945625-2945428 [Streptomyces sp. NA02536]
MAGLNLRFTDEELDALRERAAAEGRSMQTFAHDAVIKAINEHSRLFNEAADHVLRASEELNRRLA

Download         Length: 198 bp

>AT160640 NZ_CP070598:c4947497-4946739 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References