Detailed information of TA system TA160639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2915360..2915994
• Replicon: chromosome
• Accession: NZ_CP054938
• Organism: Streptomyces harbinensis strain NA02264

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HUT13_RS13105
• Protein ID: WP_093843201.1
• Coordinates: 2915572..2915994 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUT13_RS13100
• Protein ID: WP_093843202.1
• Coordinates: 2915360..2915575 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUT13_RS13085	2911010..2912356	-	1347	WP_176128192.1	AAA family ATPase	-
HUT13_RS13090	2913399..2914757	+	1359	WP_176128193.1	hypothetical protein	-
HUT13_RS13095	2914777..2915009	-	233	Protein_2576	Txe/YoeB family addiction module toxin	-
HUT13_RS13100	2915360..2915575	+	216	WP_093843202.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HUT13_RS13105	2915572..2915994	+	423	WP_093843201.1	PIN domain nuclease	Toxin
HUT13_RS13110	2916121..2917992	+	1872	WP_176128194.1	DUF4328 domain-containing protein	-
HUT13_RS13115	2918111..2918677	+	567	WP_158687214.1	hypothetical protein	-
HUT13_RS13120	2918690..2920129	-	1440	WP_176128195.1	DUF2236 domain-containing protein	-
HUT13_RS13125	2920126..2920917	-	792	WP_019434066.1	di-trans,poly-cis-decaprenylcistransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-123)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-46)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15433.30 Da
• Isoelectric Point: 4.7222

>T160639 WP_093843201.1 NZ_CP054938:2915572-2915994 [Streptomyces harbinensis]
VNAAQFLIDTSALARFMRADAEQYGWDQAAAAGLIATCPITELEFFYSARSAADRARGIEDMRLIFGWVAVDDRAYDRAW
QVQEALTKQGRHRSAGAVDLVVAATAELQGLTLLHRDHDFECIASVTGQALQWYGPEQGK

Nucleotide

• Length: 423 bp

>T160639 NZ_CP070598:c4789916-4789632 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7951.95 Da
• Isoelectric Point: 5.1070

>AT160639 WP_093843202.1 NZ_CP054938:2915360-2915575 [Streptomyces harbinensis]
MSRTVIDLDDDLVADVAKALGTSTKKETVNTALREVLESRRRALALARLRAAADDGAFDLDLFENKENYRR

Nucleotide

• Length: 216 bp

>AT160639 NZ_CP070598:c4790148-4789906 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA