Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) doc-NpoA/Fic(toxin)
Location 7737409..7738573 Replicon chromosome
Accession NZ_CP054932
Organism Actinomadura sp. NAK00032

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HUT06_RS35400 Protein ID WP_176199693.1
Coordinates 7737409..7737777 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name NpoA Uniprot ID -
Locus tag HUT06_RS35405 Protein ID WP_176199694.1
Coordinates 7737824..7738573 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT06_RS35375 7732989..7734077 + 1089 WP_176201836.1 glycine cleavage system aminomethyltransferase GcvT -
HUT06_RS35380 7734093..7734482 + 390 WP_176199689.1 glycine cleavage system protein GcvH -
HUT06_RS35385 7734479..7735735 + 1257 WP_176199690.1 serine hydroxymethyltransferase -
HUT06_RS35390 7735787..7737157 + 1371 WP_176199691.1 L-serine ammonia-lyase -
HUT06_RS35395 7737209..7737412 + 204 WP_176199692.1 hypothetical protein -
HUT06_RS35400 7737409..7737777 + 369 WP_176199693.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HUT06_RS35405 7737824..7738573 + 750 WP_176199694.1 SDR family oxidoreductase Antitoxin
HUT06_RS35410 7738595..7738954 + 360 WP_176199695.1 MerR family transcriptional regulator -
HUT06_RS35415 7738958..7739419 - 462 WP_176199696.1 nuclear transport factor 2 family protein -
HUT06_RS35420 7739511..7740095 + 585 WP_176199697.1 TetR/AcrR family transcriptional regulator -
HUT06_RS35425 7740063..7740509 - 447 WP_176199698.1 helix-turn-helix transcriptional regulator -
HUT06_RS35430 7740525..7741688 - 1164 WP_176201837.1 thiolase family protein -
HUT06_RS35435 7741857..7742114 + 258 WP_176199699.1 hypothetical protein -
HUT06_RS35440 7742252..7742608 + 357 WP_176199700.1 hypothetical protein -
HUT06_RS35445 7742872..7743024 - 153 WP_176199701.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(41-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 12297.95 Da        Isoelectric Point: 5.0487

>T160638 WP_176199693.1 NZ_CP054932:7737409-7737777 [Actinomadura sp. NAK00032]
VITPSDLVAINAALHGGEAQVRDAGLVAAAAARPSTVTFGVEAFPTTAEKAAALLHAVLGNHPFVDGNKRVGWTAARVLL
ALHGERPGLSEDEAFDLVVRVAASGADTTIAELAAALNVVPG

Download         Length: 369 bp

>T160638 NZ_CP070598:c4688071-4687538 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 25768.50 Da        Isoelectric Point: 6.4995

>AT160638 WP_176199694.1 NZ_CP054932:7737824-7738573 [Actinomadura sp. NAK00032]
MEMRSQERVALVTGAGTGIGRATARMFAAEGTRVVAVGRRAEPLAETAEGYGLIHPLAADITGEGAAEEIVRQVRDVHGR
LDVLVNNAAIVRSGALEATTPEAMDAQLATNLVAPVLLAQAALKVLGDGGVIVNVSTSVGQRAWPGNAFYAATKAALEVL
TRSWAVELAPRGVRVVAVAPGAIGTPIGRHQGLSDEQLAAVRKWQVEHTPLGRIGRPEEVAWAITRLAAPEASFVTGVVF
PVDGGAVVG

Download         Length: 750 bp

>AT160638 NZ_CP070598:c4688348-4688082 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References