Detailed information of TA system TA160635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 134719..136302
• Replicon: chromosome
• Accession: NZ_CP054931
• Organism: Stenotrophomonas sp. NA06056

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HUT07_RS00545
• Protein ID: WP_176019259.1
• Coordinates: 134719..136041 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HUT07_RS00550
• Protein ID: WP_176019260.1
• Coordinates: 136045..136302 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUT07_RS00530	130046..131680	-	1635	WP_176019256.1	TldD/PmbA family protein	-
HUT07_RS00535	131708..133339	-	1632	WP_176019257.1	TldD/PmbA family protein	-
HUT07_RS00540	134104..134718	+	615	WP_176019258.1	DUF938 domain-containing protein	-
HUT07_RS00545	134719..136041	-	1323	WP_176019259.1	type II toxin-antitoxin system HipA family toxin	Toxin
HUT07_RS00550	136045..136302	-	258	WP_176019260.1	helix-turn-helix transcriptional regulator	Antitoxin
HUT07_RS00555	136464..140150	-	3687	WP_176019261.1	indolepyruvate ferredoxin oxidoreductase family protein	-
HUT07_RS00560	140320..140955	+	636	WP_176019262.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-70)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48772.60 Da
• Isoelectric Point: 6.4321

>T160635 WP_176019259.1 NZ_CP054931:c136041-134719 [Stenotrophomonas sp. NA06056]
MGTLRVWMNGVEVALWDDVRSGSPRLSYMDPWIRSAQFRPLSLSLPLLPEGESHRGTVVNDYFDNLLPDNIAIRNRIRDR
FATRSSDTFDLLEAIGRDCVGAVQLLPPSRTPGDIQRITFEPLNDSGVAEVLRQVTTSALPGTSSSDDAFRISIAGAQEK
TGLLLHDGQWCIPTGSTPSTHIFKLPLGIGGNMRADMHQSVENEWLCMHLLAAFGIPVADTQMGRFEDQGALIVERFDRR
LAADRTWWLRLPQEDMCQVFGLPAARKYESDGGPGIVAIMDLLRQSEQPEDRATFFKTQILFWMLAATDGHAKNFSVHID
AGGRFRLTPVYDVLSVYPILGRGPNQLDPHNAQLAMAVEGKNPHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEKVTRQLPRDFPASVSEPIFKGLRAAAARLSSMAPDA

Nucleotide

• Length: 1323 bp

>T160635 NZ_CP070598:1966243-1966345 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9569.06 Da
• Isoelectric Point: 11.8858

>AT160635 WP_176019260.1 NZ_CP054931:c136302-136045 [Stenotrophomonas sp. NA06056]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAELAKQLGISRQAVGALERDPASASFERLMRVWAVLGLEVSLQKRRAPENT
STLEW

Nucleotide

• Length: 258 bp

>AT160635 NZ_CP070598:c1966351-1966207 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT