Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2789233..2789903 Replicon chromosome
Accession NZ_CP054923
Organism Verrucosispora sp. NA02020

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUT12_RS12245 Protein ID WP_131053375.1
Coordinates 2789478..2789903 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HUT12_RS12240 Protein ID WP_131053372.1
Coordinates 2789233..2789478 (+) Length 82 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT12_RS12225 2784751..2785692 + 942 WP_131055301.1 hypothetical protein -
HUT12_RS12230 2785759..2788494 - 2736 WP_176093434.1 LuxR family transcriptional regulator -
HUT12_RS12235 2788804..2789112 + 309 WP_131053373.1 N-acetyltransferase -
HUT12_RS12240 2789233..2789478 + 246 WP_131053372.1 Arc family DNA-binding protein Antitoxin
HUT12_RS12245 2789478..2789903 + 426 WP_131053375.1 type II toxin-antitoxin system VapC family toxin Toxin

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-125)

Antitoxin

(13-48)


Sequences


Toxin        


Download         Length: 142 a.a.        Molecular weight: 15188.26 Da        Isoelectric Point: 5.7035

>T160632 WP_131053375.1 NZ_CP054923:2789478-2789903 [Verrucosispora sp. NA02020]
MIVLDTNVVSELMRAEPAPVVLAWIQRNSRAGLYTTAITVAEIRYGIARLPAGQRRESLHQAANEIFAAFPRQVLPFDLG
AASAYADVVAGRDRLGHPIDGFDAQIAAICRAQAATLATRNTKDFTDTGIGVVDPWQEPSA

Download         Length: 426 bp

>T160632 NZ_CP070598:385961-386308 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8900.07 Da        Isoelectric Point: 5.8508

>AT160632 WP_131053372.1 NZ_CP054923:2789233-2789478 [Verrucosispora sp. NA02020]
MAALSIRDLDDAVREKLRRRAAQHGRSMEAEIRDILTRAVAEDAPVNDLFGALTDRFARLGGVELELPSRSTSPRAASLP
E

Download         Length: 246 bp

>AT160632 NZ_CP070598:386308-386607 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References