Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 2789233..2789903 | Replicon | chromosome |
Accession | NZ_CP054923 | ||
Organism | Verrucosispora sp. NA02020 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | HUT12_RS12245 | Protein ID | WP_131053375.1 |
Coordinates | 2789478..2789903 (+) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | HUT12_RS12240 | Protein ID | WP_131053372.1 |
Coordinates | 2789233..2789478 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUT12_RS12225 | 2784751..2785692 | + | 942 | WP_131055301.1 | hypothetical protein | - |
HUT12_RS12230 | 2785759..2788494 | - | 2736 | WP_176093434.1 | LuxR family transcriptional regulator | - |
HUT12_RS12235 | 2788804..2789112 | + | 309 | WP_131053373.1 | N-acetyltransferase | - |
HUT12_RS12240 | 2789233..2789478 | + | 246 | WP_131053372.1 | Arc family DNA-binding protein | Antitoxin |
HUT12_RS12245 | 2789478..2789903 | + | 426 | WP_131053375.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15188.26 Da Isoelectric Point: 5.7035
>T160632 WP_131053375.1 NZ_CP054923:2789478-2789903 [Verrucosispora sp. NA02020]
MIVLDTNVVSELMRAEPAPVVLAWIQRNSRAGLYTTAITVAEIRYGIARLPAGQRRESLHQAANEIFAAFPRQVLPFDLG
AASAYADVVAGRDRLGHPIDGFDAQIAAICRAQAATLATRNTKDFTDTGIGVVDPWQEPSA
MIVLDTNVVSELMRAEPAPVVLAWIQRNSRAGLYTTAITVAEIRYGIARLPAGQRRESLHQAANEIFAAFPRQVLPFDLG
AASAYADVVAGRDRLGHPIDGFDAQIAAICRAQAATLATRNTKDFTDTGIGVVDPWQEPSA
Download Length: 426 bp
>T160632 NZ_CP070598:385961-386308 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8900.07 Da Isoelectric Point: 5.8508
>AT160632 WP_131053372.1 NZ_CP054923:2789233-2789478 [Verrucosispora sp. NA02020]
MAALSIRDLDDAVREKLRRRAAQHGRSMEAEIRDILTRAVAEDAPVNDLFGALTDRFARLGGVELELPSRSTSPRAASLP
E
MAALSIRDLDDAVREKLRRRAAQHGRSMEAEIRDILTRAVAEDAPVNDLFGALTDRFARLGGVELELPSRSTSPRAASLP
E
Download Length: 246 bp
>AT160632 NZ_CP070598:386308-386607 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|
Antitoxin
Source | ID | Structure |
---|